摘要
目的 探讨低级别胶质瘤患者的临床病理特点及影响预后的因素.方法 回顾性分析经病理证实的87例低级别胶质瘤患者的临床病例资料.结果 87例患者中,男性占62.1%（54/87）,平均发病年龄36.2岁.平均随访51.4个月（3~135个月）,失访5例,随访率为94.3%（82/87）.3年生存率为84.1%,5年生存率为66.7%.3年生存率与临床表现、肿瘤最大直径和手术切除程度有关（P〈0.01或〈0.05）;5年生存率与年龄、Karnofsky评分、临床表现、肿瘤最大直径、病理类型和手术切除程度有关（P〈0.05或〈0.01）.结论 低级别胶质瘤常见于男性,好发于40岁以下的青中年患者.年龄≤40岁、Karnofsky评分≥70分、仅有癫痫症状、肿瘤最大径6.0 cm以下、病理类型为少突胶质细胞起源肿瘤、手术全切除或次全切除是积极的预后影响因子,术后放疗可降低肿瘤进展率.
Objective To investigate the clinicopathological features and prognostic factors in patients with low grade glioma. Methods Eighty- seven patients with low grade glioma confirmed by cytological examination were retrospectively analyzed. Results Among 87 patients, male accounted for 62.1%（54/87）, and the average age was 36.2 years. The average followed- up time was 51.4 months （3-135 months）, and 5 cases were lost in follow-up. The follow- up rate was 94.3% （82/87）. The 3- year survival rate was 84.1%, and the 5- year survival rate was 66.7%. The 3- year survival rate was related to clinical symptoms, maximum diameter of tumor and the extent of resection （P〈0.01 or〈0.05）;and the 5- year survival rate was related to years, Karnofsky score, clinical symptoms, maximum diameter of tumor, the pathology classification and extent of resection （P〈0.05 or〈0.01）. Conclusions Low grade glioma is more common in male patients and patients under the age of 40 years. Age below 40 years, Karnofsky score ≥ 70 scores, only epilepsy symptom, tumor diameter below 6.0 cm, oligodendrogliomas, complete resection or subtotal resection are positive prognostic factors. Postoperative radiotherapy can reduce the rate of tumor progression.
出处
《中国医师进修杂志》
2017年第3期204-207,共4页
Chinese Journal of Postgraduates of Medicine
