摘要
目的研究血清前蛋白转化酶枯草溶菌素9(PCSK9)在冠心病慢性心力衰竭中的变化和临床意义。方法选取2016年1~8月我院心内科符合诊断要求的45例冠心病慢性心力衰竭患者作为病例组,同时选取40例无心力衰竭的冠心病患者作为对照组,比较两组的血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、PCSK9、高敏C反应蛋白(hsCRP)的浓度。所有患者均于入院第2天早晨空腹抽取外周静脉血5 ml,病例组治疗后再次抽取外周静脉血5 ml,测定血清PCSK9、hsCRP水平。结果两组的TC、TG、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05)。病例组治疗前的PCSK9及hsCRP水平显著高于对照组治疗前,差异有统计学意义(P<0.05)。病例组治疗前后的血浆PCSK9、hsCRP水平比较,差异有统计学意义(P<0.05);对照组治疗前后的PCSK9、hsCRP水平比较,差异无统计学意义(P>0.05)。病例组治疗后的PCSK9、hsCRP水平显著低于对照组治疗后,差异有统计学意义(P<0.05)。结论患者血清PCSK9水平与慢性心力衰竭密切相关,其可能通过促炎症反应参与慢性心力衰竭的发病过程,可为临床预测及寻找新的慢性心力衰竭治疗及干预措施提供新思路。
Objective To study the changes of serum proprotein convertase subtilisin/kexin 9 （PCSK9） levels in patients with coronary heart disease combined with chronic heart failure and its clinical significance.Methods 45 patients who met the diagnostic requirements of coronary heart disease with chronic heart failure from January to August in 2016 of Internal Medicine-Cardiovascular Department in our hospital were selected as the case group.40 coronary heart disease patients without chronic heart failure were selected as the control group.The concentration of total cholesterol （TC）, triglyceride （TG）,low density lipoprotein cholesterol （LDL-C）,high density lipoprotein cholesterol （HDL-C）,PCSK9 and high sensitive C reaction protein （hsCRP） in the two groups were compared.All the patients were collected fasting blood 5 ml at the second day of admission and the case group were collected peripheral venous blood 5 ml after treatment to test the level of serum PCSK9 and hsCRP.Results There was no significant difference in the level of TC,TG,LDL-C, HDL-C between the two groups （P〉0.05）.The level of PCSK9 and hsCRP before treatment in the case group was signif- icantly higher than that in the control group before treatment,with significant difference （P〈0.05）.There was significant difference in the level of plasma PCSK9 and hsCRP before and after treatment in the case group （P〈0.05）.There was no significant difference in the level of PCSK9 and hsCRP before and after treatment in the control group （P〉0.05）.The levels of PCSK9 and hsCRP after treatment in the case group was lower than that in the control group after treatment, with significant difference （P〈0.05）.Conclusion The serum PCSK9 level is closely related to chronic heart failure,which may be involved in the pathogenesis of chronic heart failure by promoting inflammation,and can provide new ideas for clinical prediction and search for new treatment and intervention measures for chronic heart failure.
作者
武春艳
WU Chun-yan(patients with coronary heart disease and its clinical significance Department of Internal Medicine-Cardiovascular,the Third Hospital Affiliated to Nanhua University,HuMan Province, Hengyang 421900,China)
出处
《中国当代医药》
2017年第13期38-40,44,共4页
China Modern Medicine
基金
湖南省卫生计生委科研计划课题项目(B2016138)
关键词
前蛋白转化酶枯草溶菌素9
慢性心力衰竭
高敏C反应蛋白
Proprotein convertase subtilisin/kexin 9
Chronic heart failure
High sensitive C reaction protein
