摘要
目的:探讨脑血管支架植入术后再狭窄患者血清S1P、HC-Ⅱ水平与血管活性物质、细胞因子的关系。方法:收集在本院接受脑血管支架植入术且出现再狭窄的患者52例作为观察组,另取同期在本院进行复查的健康脑血管支架植入术后患者40例作为对照组。采用ELISA法检测血清S1P、HC-Ⅱ水平及血管活性物质、炎症因子含量。采用Spearman相关分析评估血清S1P、HC-Ⅱ水平与血管活性物质、炎症因子的关系。结果:观察组血清S1P、HC-Ⅱ水平低于对照组(P<0.05);观察组血清中血管活性物质ET、AngⅡ、TXB2含量高于对照组,NO含量低于对照组(P<0.05);观察组血清炎症因子hs-CRP、IL-1、IL-6、IL-8、IL-11含量高于对照组(P<0.05)。脑血管支架植入术后再狭窄患者血清S1P、HC-Ⅱ水平与血管活性物质、炎症因子含量存在直接相关关系。结论:脑血管支架植入术后再狭窄患者血清S1P、HC-Ⅱ水平降低,是导致脑血管功能异常、全身炎症反应的重要原因。
Objective：To study the relationship of serum S1 Pand HC-Ⅱ levels with vasoactive substances and cytokines in patients with cerebral vascular restenosis after stent implantation.Methods：A total of 52 patients who received cerebrovascular stent implantation and developed restenosis in our hospital between May 2012 and December 2015 were collected as observation group,and 40 healthy patients with cerebrovascular stent implantation who had re-examination in our hospital during the same period were selected as control group.ELISA method was used to detect serum S1 Pand HC-Ⅱ levels as well as vasoactive substance and inflammatory factor contents.Spearman correlation analysis was used to evaluate the relationship of serum S1 P and HC-Ⅱ levels with vasoactive substances and inflammatory factors.Results：Serum S1 Pand HC-Ⅱ levels of observation group were lower than those of control group（P〈0.05）;serum vasoactive substances ET,AngⅡ and TXB2 contents of observation group were higher than those of control group while NO content was lower than that of control group（P〈0.05）;serum inflammatory factors hs-CRP,IL-1,IL-6,IL-8and IL-11 contents of observation group were higher than those of control group（P〈0.05）.Serum S1 Pand HC-Ⅱ levels in patients with cerebral vascular restenosis after stent implantation were directly correlated with vasoactive substance and inflammatory factor contents.Conclusions：Serum S1 Pand HC-Ⅱ levels decrease in patients with cerebral vascular restenosis after stent implantation,and it is an important cause of cerebral vascular dysfunction and systemic inflammatory response.
出处
《海南医学院学报》
CAS
2017年第7期966-968,972,共4页
Journal of Hainan Medical University
基金
重庆市万州区科技计划项目(KJ20130108)~~
