摘要
目的探讨超高龄胃癌(gastric cancer,GC)患者的临床病理特征与生存状况,明确影响患者生存状况的相关因素.方法2010-02/2011-05浙江省台州医院收治的G C患者426例,依据年龄分为超高龄组和非超高龄组,比较两组患者的临床病理资料和1年、3年、5年生存率,并对超高龄GC患者的临床资料进行多因素COX比例风险模型分析.结果超高龄组患者的年龄、合并高血压、贫血、肿瘤直径>5 cm、高分化肿瘤、输血比例明显高于非超高龄组,差异具有统计学意义(P<0.05).超高龄组82例,1年、3年、5年生存率分别为62.20%、42.68%、25.61%;非超高龄组344例,1年、3年、5年生存率分别为75.00%、54.94%、36.34%.男性、高血压、肿瘤直径>5 cm、TNM分期Ⅲ-Ⅳ期、低分化、输血是影响超高龄GC患者生存状况的独立危险因素(P<0.05).结论超高龄GC患者合并高血压、贫血、肿瘤直径及输血比例较大,但低分化肿瘤较少,生存状况普遍不佳,主要受性别、高血压、肿瘤直径、TNM分期等因素的影响.
AIM To investigate the clinicopathological features and survival of very elderly patients with gastric cancer （GC）, and to identify the factors influencing the survival of these patients.METHODS Four hundred and twenty-six GC patients treated at our hospital from February 2010 to May 2011 were divided into either a very- elderly age group （n = 82） or a non-very- elderly age group （n = 344） based on the age. Clinicopathological data and 1-, 3-, and 5-year survival were compared between the two groups. Clinical data for very elderly GC patients were analyzed with the multivariate COX proportional hazards model to identify the risk factors for the survival of these patients.RESULTS Age, hypertension, anemia, tumor diameter 〉 5 cm, well-differentiated tumor and transfusion ratio were significantly higher in the very- elderly age group than in the non-very-elderly age group （P 〈 0.05）. The survival rates at 1, 3 and 5 years were 62.20%, 42.68% and 25.61%, respectively, for the very-elderly age group, and 75.00%, 54.94% and 36.34%, respectively, for the non-very-elderly age group. TNM stage III-IV, poor differentiation and transfusion were identified to be independent risk factors for the survival of very elderly GC patients （P 〈 0.05）.CONCLUSION Very elderly patients with GC tend to have high blood pressure, anemia, large tumor diameter and high transfusion ratio; however, poorly differentiated tumors are rare and the survival status is generally poor in these patients, perhaps mainly due to gender,hypertension, tumor diameter and TNM stage.
作者
周晶晶
蔡菊芳
Jing-Jing Zhou Ju-Fang Cai(Department of Pathology, Zhejiang Taizhou Hospital, Linhai 317000, Zhejiang Province, China)
出处
《世界华人消化杂志》
CAS
2017年第11期1021-1025,共5页
World Chinese Journal of Digestology
关键词
超高龄
胃癌
病理特征
生存状况
Very elderly
Gastric cancer
Pathological characteristics
Survival status
