摘要
背景:在骨修复中,组织工程可以作为一种新的方法取代自体骨移植。其中支架是组织工程技术的重要元素,而3D打印技术可以在其制作过程中实现精确的调控,因此有关3D打印技术在支架制作中的应用受到越来越多的关注。目的:对现有关于3D打印支架应用于骨缺损修复的体外或体内研究进行回顾,以期为未来的科研及临床提供新的依据。方法:由第一作者从Pub Med数据库中,以"tissue engineering;bone;three-dimensional printing;scaffold"为关键词检索2003年1月至2016年3月间发表的文献,筛选出与3D打印组织工程支架相关的文献。结果与结论:目前已有大量关于3D打印组织工程支架的研究,支架的材料选择和表面修饰逐渐成为研究热点。如今支架材料适当的孔隙率已成为设计中必不可少的元素,越来越精细的加工手法也提升了支架的各项性能,而在材料的选择上也越来越多的偏向于复合材料而不是单一的同种材料,这些措施不仅提高了机械性能,还促进了细胞附着和生长繁殖,最后对于支架的各种促成骨表面处理,更是在细胞分子水平上促进了机体与植入材料间的互相作用。体内外的研究结果均显示复合材料且表面涂布骨诱导涂层均可以不同程度地提高支架性能和促进成骨。
BACKGROUND： The tissue-engineered scaffold, as a substitute of autogenous bone graft, plays an important role in bone repair. In the meanwhile, three-dimensional （3D） printing technology has obtained more attention because of its accurate adjustment.OBJECTIVE： To review the in vitro or in vivo studies on the 3D-printed scaffolds applied in bone repair, thus providing basis for clinical research.METHODS： The first author searched the PubMed database using the English keywords of ＂tissue engineering, bone,three-dimensional printing, scaffold＂ for pertinent articles addressing 3D-printed tissue-engineered scaffolds.RESULTS AND CONCLUSION： There are plenty of studies on 3D-printed tissue-engineered scaffolds, and recent research focuses on the material selection and surface modification. The appropriate porosity is vital, and with the development of manufacturing technology, each property of the scaffold is improved, and composite materials prevail gradually. All above improvements enhance the mechanical property and promote cell adhesion and proliferation.Furthermore, the surface modification promotes the implant-bone interaction. In vivo and in vitro research both indicate that composite materials with the surface coating of bone induction can improve the scaffold performance and osteogenesis.
出处
《中国组织工程研究》
CAS
北大核心
2017年第10期1611-1616,共6页
Chinese Journal of Tissue Engineering Research
基金
上海市科学技术委员会科研计划项目(124119b0103)~~
关键词
生物材料
骨生物材料
骨
3D打印
支架
,Biocompatible Materials
Braces
Alveolar Process
Tissue Engineering
