摘要
目的了解寿光市自然人群乙型肝炎病毒(hepatitis B virus,HBV)慢性感染者HBV DNA的流行病学特征,为乙型肝炎的防治提供依据。方法采集2012年寿光市3个镇街道居民体检发现的HBs Ag阳性者静脉血5 m L,以实时荧光定量聚合酶链反应(FQ-PCR)法检测血清HBV DNA载量,分析HBV DNA与性别、年龄、有无乙肝/肝癌家族史、密切接触史、输血史等因素的相关性。结果在2 026例HBs Ag阳性感染者中,HBV DNA阳性率为49.41%(1 001/2 026),HBV DNA载量的平均值为6.27×107拷贝/m L。其中男性HBV DNA阳性率为53.28%(585/1 098),女性为44.83%(416/928),差异有统计学意义(χ2=14.370,P<0.01);HBV DNA均值男性为(6.72×107±2.07×108)拷贝/m L,女性为(5.56×107±1.44×108)拷贝/m L,差异无统计学意义(t=0.447,P>0.05)。HBVDNA阳性率与年龄呈负相关(r=-0.983),与HBV感染的主要影响因素乙肝/肝癌家族史、密切接触史、输血史等均无关。结论 HBV DNA阳性率与慢性HBV感染者的性别、年龄有关,与HBV感染的主要影响因素无关。
Objective To understand the epidemiological characteristics of HBV DNA among individuals with chronic hepatitis B virus infection in natural population in Shouguang City, and to provide the related control support. Methods To collect each 5mL blood sample from the residents in three towns, whose HBsAg were positive detected in 2012. The HBV DNA loading amount in serum was tested by FQ-PCR to analyse the relationship about HBV DNA and gender, age, family medical history of hepatitis B and related liver cancer, history on eontaction and blood transfusion. Results The HBV DNA positive rate was 49.41% （ 1 001/2 026） in a total of 2016 HBsAg positive samples, and HBV DNA average loading amount was 6.27× 10^7copy/mL. The positive rate of male was 53.28% （585/1 098） while female was 44.83% （416/ 928 ） , and the difference was statistically significant, （Х^2= 14. 370,P〈0.01 ）between male and female. The mean number of HBV DNA was 6.72×10^7±2.07×10^8 among male group but 5.56×10^7±1.44×10^8 among female group, there was no a statistical meaning（t = 0. 447,P〉0.05）. In addition, the positive rate of HBV DNA was negatively related to age（r = -0. 983 ） , the major influencial factors, such as family history of liver cancer and HBV, contaction history and blood transfusion history, were not related with the positive rate of HBV DNA. Conclusion The positive rate of HBV DNA was only related to age and gender of individuals with chronic HBV infection, but not related to the major influencial factors.
出处
《微生物学免疫学进展》
2017年第2期53-56,共4页
Progress In Microbiology and Immunology
基金
基金项目:艾滋病和病毒性肝炎等重大传染病防治(2013ZX10004902)
