摘要
目的探讨急性胰腺炎(AP)患者血清垂体中叶素(IMD)及降钙素原(PCT)动态变化监测的临床价值。方法选取我院2013年1月至2016年9月急性胰腺炎患者91例作为研究对象,所有患者均于入院时、第3天、第5天、第7天采集静脉血,采用酶联免疫吸附法测定PCT,同时进行APACHEⅡ评分;根据患者急性胰腺炎严重程度分为轻症胰腺炎(MAP)组49例和重症胰腺炎(SAP)组42例。比较两组IMD及PCT动态变化。结果组内比较,两组患者第3天、第5天、第7天IMD均低于入院时,第3天PCT明显高于入院时,差异均有统计学意义(P<0.05);MAP组第5天、第7天PCT明显低于入院时,SAP组第5天PCT高于入院时,第7天低于入院时,差异均有统计学意义(P<0.05);组间比较,MAP组患者入院时、第3天、第5天、第7天IMD均高于SAP组,PCT均低于SAP组,差异均有统计学意义(P<0.05);MAP组患者24 h APACHEⅡ评分为(4.54±0.98)分,明显低于SAP组的(15.09±3.72)分,差异有统计学意义(P<0.05);MAP组、SAP组APACHEⅡ评分与IMD的相关系数分别为-0.089、-0.118,呈负相关;与PCT相关系数分别为0.194、0.233,呈正相关(P<0.01)。结论血清IMD及PCT可在一定程度上反映AP严重程度及疗效,具有较高的临床价值。
Objective To investigate the clinical value of dynamic change monitoring of intermedin（IMD）and procalcitonin（PCT） in patients with acute pancreatitis（AP）. Methods A total of 91 patients with AP in our hospital from January 2013 to September 2016 were selected as research objects. Venous blood samples of all patients were collected on day 0, day 3, day 5, day 7. PCT was detected by enzyme-linked immunosorbent determination, and the APACHE Ⅱ score was detected simultaneously. The patients were divided into moderate acute pancreatitis（MAP）group（n=49）, and severe acute pancreatitis（SAP） group（n=42） according to the severity of acute pancreatitis. The dynamic changes of IMD and PCT between the two groups were compared. Results The dynamic value of IMD on day3, day 5, day 7 of two groups were significantly lower than those at admission, but the PCT on 3 d were significantly higher than that at admission（P〈0.05）. The dynamic value of PCT on day 5, day 7 of MAP group was significantly lower than that at admission. The PCT on day 5, day 7 of SAP group were significantly higher than those at admission, and that on day 7 was significantly lower than that at admission（P〈0.05）. The IMD values of patients at admission, on day 3,day 5, day 7 of MAP group were significantly higher than those of SAP group, but the PCT was significantly lower（P〈0.05）. The APACHE Ⅱscore within 24 h in MAP group was（4.54±0.98）, which was significantly lower than the（15.09±3.72） in SAP group（P〈0.05）. APACHE score of MAP group and SAP group were negatively correlated with IMD（r=-0.089, r=-0.118）. However, APACHE score of MAP group and SAP group were positively correlated with PCT（r=0.194, r=0.233）, P〈0.01. Conclusion Serum IMD and PCT can reflect the severity and efficacy of AP to some extent,which have high clinical value.
出处
《海南医学》
CAS
2017年第7期1096-1097,共2页
Hainan Medical Journal
关键词
急性胰腺炎
垂体中叶素
降钙素原
动态监测
Acute pancreatitis（AP）
Intermedin（IMD）
Procalcitonin（PCT）
Dynamic monitoring
