摘要
目的探索儿童环境危险因素对儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)发生风险的影响。方法采用病例-对照研究的流行病学方法,收集2015年在天津市血液病医院就诊的儿童ALL作为病例组,选取同期同地区的健康儿童作为对照组。通过一对一问卷调查的方式收集研究对象的相关信息。通过单因素x^2检验和多因素非条件Logistic回归模型,分析儿童环境危险因素与ALL发生关联情况,并计算相关危险因素的人群归因危险度百分比(population attributable risk percent,PARP)。结果单因素分析结果显示,病例组中接触油漆涂料(x^2=7.146,P=0.008)、不爱吃蔬菜和水果(x^2=47.070,P<0.001)以及出生后居室装修(x^2=9.030,P=0.003)的儿童发生ALL的比例均高于对照组。多因素分析结果显示,接触油漆涂料(OR=2.174,95%CI:1.031~4.583)、不爱吃蔬菜和水果(OR=4.990,95%CI:3.017~8.253)和出生后居室装修(OR=2.831,95%CI:1.361~5.889)与儿童ALL的发生相关。上述三种危险因素的PARP分别为11.2%、25.2%和11.7%。结论油漆涂料接触史、不爱吃蔬菜和水果及出生后居室装修可能是儿童患ALL的危险因素。
Objective To explore the association between environmental risk factors and childhood acute lymphoblastic leukemia （ALL）.Methods Children with ALL from Tianjin Blood Disease Hospital in 2015 were enrolled in this case-control study.Controls were randomly selected from health children during the same period.Information was collected by one-on-one questionnaire.Chi-square test and non-conditional Logistic regression model were used to analyze the association between environmental risk factors and ALL.The adjusted population attributable risk percent （PARP） for the related risk factors were calculated.Results Single factor analysis showed that children with history of contacting with the paints and coatings（χ^2 =7.146,P =0.008）,eat less vegetables and fruits（χ^2 =47.070,P 〈 0.001） and exposure to home decoration（χ^2 =9.030,P =0.003） in case group were more than those in control group.Results from multivariate analysis also showed these three factors were significantly associated with ALL,with odds ratios of 2.174 （1.031-4.583）,4.990 （3.017-8.253） and 2.831 （1.361-5.889） respectively,and the PARP of the three factors were 11.2%,25.2% and 11.7% respectively.Conclusions Contacting with the paints and coatings,partiality for a particular kind of food and exposure to home decoration could be risk factors for childhood ALL.
作者
赵亮
曾强
张丽
张丹丹
张磊
王睿
符刚
冯宝佳
刘晓明
ZHAO Liang ZENG Qiang ZHANG Li ZHANG Dan-dan ZHANG Lei WANG Rui FU Gang FENG- Bao-jia LIU Xiao-ming(Institute of Environment and Health, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China Department of Pediatrics, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianfin 300020, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第4期375-378,共4页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81200396)
天津市卫生计生委科技基金(2014KR12)
天津市疾病预防控制中心科技基金(CDCKY1406)
关键词
白血病
双表型
急性
危险因素
流行病学方法
Leukemia, biphenotypie, acute
Risk factors
Epidemiologic methods
