摘要
目的通过对青海地区236株结核分枝杆菌(mycobacterium tuberculosis,M.tb)进行分离培养与耐药性检测,了解青海地区结核病(tuberculosis,TB)的耐药现状,为青海地区结核病防治提供参考依据。方法对青海地区分离的236株结核分枝杆菌用改良罗氏培养基进行培养,采用比例法进行耐药性检测,分析该地区结核病耐药状况与人口学特征的关系,并对结果进行统计分析。结果 236株结核分枝杆菌总耐药率为55.93%(132/236);四种一线药物耐药率由高到低依次是异烟肼(isoniazid,INH)为43.22%,链霉素(streptomycin,SM)为38.14%,利福平(rifampin,RFP)为37.29%,乙胺丁醇(ethambutol,EMB)为28.81%;单耐药结核病(single drug resistance tuberculosis,SDR-TB)比例为12.71%;耐多药结核病(multidrug resistant tuberculosis,MDR-TB)和广泛耐药结核病(extensivelydrug resistant tuberculosis,XDR-TB)所占比例分别是30.93%(73/236)和1.27%(3/236);青海地区的结核分枝杆菌耐药状况与地区和年龄有关(均有P<0.05),与性别和民族无关(均有P>0.05)。结论青海地区耐药结核病比率高于全国水平,要加强该地区结核病的预防控制,对结核病患者进行规范化治疗。
Objective Through 236 strains of mycobacterium tuberculosis（ M. tb） insolation and cultivation to explore drug resistance situation of mycobacterium tuberculosis which circulating in Qinghai area,so as to provide reference for TB prevention and control in this area. Methods A total of 236 strains of mycobacterium tuberculosis isolated in Qinghai were cultured with L-J medium. Drug resistance was tested by using the proportional method. The relationship between TB drug resistance and the demographic characteristics were analyzed. Results The results showed that drug resistance rate of 236 mycobacterium tuberculosis was 55. 93%（ 132/236）. Resistance rates of four first-line drugs from high to low were 43. 22% for isoniazid,38. 14% for streptomycin,37. 29% for rifampin and 28. 81% for ethambutol. MDR-TB and XDR-TB were 30. 93%（ 73/236） and 1. 27%（ 3/236） respectively. The ratio of SDR-TB was 12. 71%. This drug-resistance TB were associated with regions and ages（ all P〈0. 05）,but were not associated with gender and ethnicity（ all P〈0. 05）. Conclusions The drug-resistance TB of Qinghai is higher than the national level. Measures of prevention and standardized treatment of tuberculosis patients should be strengthened in this area.
作者
申秀丽
蒋明霞
王兆芬
李斌
马斌忠
文国颖
姚雪琼
李婷婷
杜文琪
宋心怡
SHEN Xiu-li JIANG Ming- xia WANG Zhao-fen LI Bin MA Bin-zhong WEN Guo-ying YAO Xue-qiong LI Ting-ting DU Wen-qi SONG Xin-yi(Department of Public Health, Qinghai Medical University, Xining 810008, China Institute for Commu- nicable Disease Control and Prevention, Qinghai Center for Disease Control and Prevention, Xining 810007, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第4期353-356,共4页
Chinese Journal of Disease Control & Prevention
基金
青海省自然科学基金(2014-ZJ-910)
关键词
结核
广泛耐药性
青海省
Mycobacterium tuberculosis
Drug resistance
Qinghai
