摘要
目的 探讨电磁辐射损伤效应机制中儿茶酚胺的作用。方法 采用高效液相色谱法检测电磁辐射后 0、8、2 4、4 8h大鼠血清、海马组织去甲肾上腺素 (NE)、肾上腺素 (E)、多巴胺 (DA)的含量变化 ,并且观察了铝箔全身屏蔽和躯干屏蔽两种防护措施对儿茶酚胺的影响。结果 无屏蔽大鼠辐射后血清和海马组织中的儿茶酚胺即刻均明显升高 ,差异有显著性 (P <0 .0 1或P <0 .0 5 ) ,8h有所下降 ,2 4h再次上升 ,4 8h海马组织NE、DA仍处于较高水平 (P <0 .0 1) ,血清中NE、DA接近对照组 ;全身屏蔽辐射后儿茶酚胺含量无明显变化 ;躯干屏蔽组 6 5W/cm2 辐射后只有 2 4h时相点明显升高(P <0 .0 5 ) ;躯干屏蔽组 12 9W/cm2 辐射后儿茶酚胺含量变化趋势与未屏蔽组类似 ,且其升高幅度接近甚至超过未屏蔽组。结论 儿茶酚胺可能参与了电磁辐射对动物中枢神经系统及心血管系统的损伤 ,且中枢神经系统损伤效应持续时间长于外周心血管系统。全身屏蔽的防护效果最好 ,在对电磁辐射采取防护措施中 。
Objective To study the role of catecholamine(CA) in the mechanism of bio effect of electromagnetic irradiation. Methods The contents of norepinephrine(NE),epinephrine(E) and dopamine(DA) in serum and hippocampus of rats at 0,8,24,48 hours after electromagnetic irradiation were measured by using high performance liquid chromatography with electrochemical detector(HPLC ECD),and the influence of two kinds of shelter on CA was studied. Results The levels of CA in serum and hippocampus increased obviously in an instant,decreased at 8 h and increased significantly again at 24 h after irradiation without shielding irradiation.But at 48 h,the levels of NA,DA in hippocampus were still higher and the serum's NA,DA were not different from the control.After irradiation with whole body shielding,the levels of CA had no changes.The contents of CA increased significantly only at 24 h after irradiation by 65 W/cm 2 electromagnetic wave with trunk shielding.After irradiation by 129 W/cm 2 with trunk shielding,the change of CA were similar to that of no shielding. Conclusion CA may take part in the injury to central nervous system and cardiovascular system after electromagnetic irradiation.And the injury to central nervous system may sustain longer than that of cardiovascular system.The protective effect of whole body shielding is the best,while trunk shielding may have some protective effect following lower and middle power electromagnetic wave.The most important protective measure is to shield the head.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2002年第4期269-272,共4页
Chinese Journal of Industrial Hygiene and Occupational Diseases
