血清γ-谷氨酰转肽酶水平与2型糖尿病患者胰岛素抵抗的关系被引量：6

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摘要目的分析2型糖尿病(T2DM)患者血清γ-谷氨酰转肽酶(GGT)水平与胰岛素抵抗的相关性,探讨GGT在T2DM发病中的意义。方法选取初诊T2DM患者392例,按照血清GGT水平的四分位数分为4个水平,分别为Q1(≤16.2 U/L)98例、Q2(16.3~27.0 U/L)95例、Q3(>27.1~39.9 U/L)99例、Q4(>39.9 U/L)100例。收集患者BMI、血压、TC、TG、LDL-C、HDL-C、ALT、AST、GGT、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、C肽(FCP)及胰岛素抵抗指数(HOMA-IR)等指标。采用Pearson相关分析法及Logistic回归法分析血清GGT水平与HOMA-IR的相关性。结果 GGT为Q4水平者的HOMA-IR高于Q1、Q2、Q3水平者,Q3水平者高于Q1、Q2水平者,Q2水平者高于Q1水平者(P均<0.05)。Pearson相关性分析示,GGT与HOMA-IR呈正相关(r=0.793,P<0.05)。血清GGT水平是T2DM患者HOMA-IR的影响因素(P<0.05)。结论 T2DM患者血清GGT水平与胰岛素抵抗相关,血清GGT水平较高者HOMA-IR较高,可作为预测T2DM发生风险的参考指标。

作者商书霞宋光耀刘晓耕岳珂郭丽张建华李玲

机构地区冀中能源峰峰集团有限公司总医院河北省人民医院

出处《山东医药》 CAS 北大核心 2017年第14期56-58,共3页 Shandong Medical Journal

基金河北省卫生厅医学科学重点课题资助项目(20160744)

关键词 2型糖尿病 Γ-谷氨酰转移酶胰岛素抵抗氧化应激

分类号 R589.1 [医药卫生—内分泌]

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