摘要
目的:探讨内镜手术治疗造血干细胞移植(HSCT)后重度出血性膀胱炎(HC)的疗效及预后。方法:回顾性分析2014年12月~2016年2月在北京大学人民医院接受内镜手术治疗的9例重度HC患者的临床资料,所有患者均在诊断Ⅲ度HC后通过保守治疗2周以上效果不佳,结合国内外相关文献,总结重度HC的手术治疗经验。结果:纳入研究的HC患者共9例,其中男6例,女3例,平均年龄36.6(16~57)岁。9例HC患者共进行14次手术,平均手术时间为83.5(42~227)min,围手术期均无严重并发症发生。9例中经内镜手术后HC好转的共7例,其中4例经1次手术后好转,2例因再次血尿行二次内镜手术治疗后好转,1例因反复血尿致膀胱填塞,共行3次内镜手术后好转。另2例患者术后死于非手术相关的肺部感染。结论:内镜手术治疗HSCT术后重度HC是安全有效的,但对手术时机的合理把握对手术成功至关重要。
Objective：To investigate the therapy and outcome of endoscopic surgery for hemorrhagic cystitis（HC）after hematopoietic stem cell transplantation（HSCT）.Method：From December 2014 to February 2016,nine patients with severe HC after HSCT received endoscopic surgery. We analyzed their medical records and summarized the clinical experience and outcome referring to recent literature.Result：Among the nine patients,six were males and the left three were females,with the average age of 36.6（range,16-57）years old.Fourteen endoscopic operations were performed on the nine patients,with the average operation time of 83.5（range,42-227）min,without perioperative complications.Among the nine patients,seven of them were cured by endoscopic surgery,but other two patients died of pulmonary infection which was not related to operation.Of the seven patients,four of them received one operation,two of them were cured upon two operations for hematuria again,and one patient underwent three operations due to the repeated bladder tamponade.Conclusion：The endoscopic surgery is effective and safe for HC patients after HSCT,but the indication of surgery is the key point for the success of surgery.
出处
《临床泌尿外科杂志》
2017年第4期281-285,共5页
Journal of Clinical Urology
关键词
出血性膀胱炎
造血干细胞移植
内镜手术
hemorrhagic cystitis
hematopoietic stem cell transplantation
endoscopic surgery
