摘要
对于终末期肝衰竭患者,目前在临床中普遍应用的肝移植是较为有效的治愈方法之一。但肝移植存在手术费用昂贵、供体短缺以及术后需长期服用免疫排斥药物等诸多短期难以解决的问题,导致许多肝衰竭患者得不到有效治疗而病死。近年来,随着对间充质干细胞的深入研究,为众多疾病尤其是终末期肝病的治疗提供了新思路及新疗法,为再生医学开创了一个全新领域,其有着巨大的发展和应用前景,是肝衰竭患者尤其是终末期患者的福音。目前充质干细胞作为较理想的移植细胞和基因移植治疗的种子细胞,其研究进展倍受关注。本文拟对间充质干细胞移植治疗终末期肝衰竭的研究进展进行系统阐述。
For patients with end-stage liver failure, liver transplantation is the most direct and effective treatment options. However, there are many problems that are difficult to be solved in liver transplantation,such as high cost of operation, shortage of donors and long-term use of immunosuppressive drugs, which led to the death of patients. In recent years, the study of mesenchymal stem cells （MSCs） provides a new way to the treatment of many diseases,especially in the treatment of end-stage liver diseases, which has great development and application prospects and is the gospel for patients with end-stage liver diseases. Currently,as an ideal cell transplantation and gene therapy seed cells,the research of mesenchymal stem cells are highly concerned. In this paper, the research progress of mesenchymal stem cell transplantation in the treatment of end-stage liver failure is reviewed.
出处
《中国肝脏病杂志（电子版）》
CAS
2017年第1期7-10,共4页
Chinese Journal of Liver Diseases：Electronic Version
关键词
间充质干细胞
细胞移植
肝功能衰竭
Mesenchymal stem cells
Cell transplantation
Liver failure
