摘要
目的探讨新型纳米仿生补片在腹壁疝修补治疗中应用的可行性。方法选择新西兰大白兔25只,通过建立兔腹壁肌肉缺损区的疝模型,术后1周观察动物腹壁突出情况。采用一期修补的方式,使用新型纳米仿生补片无张力修补腹壁疝,观察术后切口感染、疝复发等并发症。取出包括网片在内的腹壁全层,做组织学观察和免疫组化研究。结果未发现手术及麻醉并发症,也未发现补片感染的案例,所有修补模型未发现复发。新型纳米补片几乎不引起腹腔粘连,术后6个月内新型纳米仿生补片变性吸收,胶原纤维增生,被结缔组织所替代,逐渐形成一致密结缔组织层。结论我们可以通过切除腹壁2 cm×3 cm全层腹壁组织结构获得稳定的动物疝模型,此新型纳米仿生补片可能是一种较为理想的腹外疝修补材料。
Objective To determine whether the host tissue responses in the abdominal hernia rabbit model and explore the feasibility of repairing the hernia with biotic mesh. Methods To establish the model of incisional hernia, full structure of abdominal wall （muscle and peritoneum） of rabbits was cut by size of 2 cm ~ 3 cm. Protruding abdominal mass of rabbits was observed one week later. The incisional hernias were repaired with Manometer bionic mesh in the one-stage operation. The complications, including infection of incisional wound and recurrence of hernia, were observed. Full-thickness sections of abdominal wall were evaluated by histological and immunohistochemical analysis. Results No intraoperative or anesthesia-related complications or mesh infection were recorded. We were able to establish the model of incisional hernia one week postoperatively and typically. No recurrent hernia was found in one stage repair. There were few intraperitoneal adhesions induced by the Manometer bionic mesh. The Manometer bionic mesh became changed and absorbed subsequently with collagen proliferation and turned to be dense connective tissue at 6 months after operation. Conclusions Removal of abdominal tissues by size of 2 cm × 3 cm can build a stable model of incisional hernia. The nanometer bionic mesh may be an ideal mesh for repairing abdominal external hernia.
出处
《中华普通外科学文献（电子版）》
2017年第2期85-88,共4页
Chinese Archives of General Surgery(Electronic Edition)
基金
广东省科技计划项产学研合作项目(2014B090901066)
广东省自然科学基金-博士启动项目(2015A030310052)
广州市产学研协同创新重大专项项目(2060404)
广东省医学科研基金项目(B2013127)
关键词
疝
纳米技术
仿生材料
兔
病理学
Henia
Nanotechnology
Bionics
Rabbits
Pathology
