摘要
[目的]观察疏肝化瘀汤联合西药治疗肝郁血瘀肝纤维化疗效。[方法]使用随机平行对照方法,将60例住院及门诊患者按就诊顺序号方法简单随机分两组;根据不同病情,恩替卡韦抗病毒,甘草酸二铵,还原型谷胱甘肽,茵栀黄等保肝降酶退黄;螺内酯,呋噻米利尿及对症治疗。对照组30例复方鳖甲软肝片,4片/次,3次/d。治疗组29例疏肝化瘀汤(柴胡12g,当归15g,赤白芍、炒白术、丹参、鳖甲^(捣碎先煎)各15g、土鳖虫10g,黄芪15g,桃仁10g,炙甘草6g,随证加减),1剂/d,水煎150mL,早晚口服。连续治疗6个月为1疗程。观测临床症状、症状积分、肝功能、肝纤四项、门静脉内径、脾静脉内径、脾脏厚度、肝脏硬度、不良反应。治疗1疗程,判定疗效。[结果]治疗组临床痊愈18例,有效9例,无效2例,总有效率93.10%;对照组临床痊愈12例,有效8例,无效10例,总有效率66.67%;治疗组疗效优于对照组(P<0.05)。症状积分、ALT、AST、TBil、ALB、PCIII、LN、HA、IV-C、肝脏硬度改善治疗组优于对照组(P<0.01)。[结论]疏肝化瘀汤联合西药治疗肝郁血瘀肝纤维化,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Shugan Huayu Decoction Combined with western medicine treatment of liver qi stagnation and blood stasis type of hepatic fibrosis. [Method] Using random parallel control method, 60 cases of inpatient and outpatient were randomly divided into two groups randomly, simple method; according to the different condition, entecavir, diammonium glycyrrhizinate, glutathione, Yinzhihuang and hepatoprotectiv jaundice treatment; spironolactone and furosemide such as diuretic therapy and other supportive treatment. The control group of 30 cases of compound Biejiarnangan tablets, 4 tablets each time, 3 times/d. The treatment group of 29 cases of Shuganhuayu Decoction （Radix 12g, angelica 15g, red peony root, white atractylodes rhizome, Salvia miltiorrhiza, turtle 15g （mashed fried）, wood louse insects 10g, Astragalus 15g, peach 10g, licorice 6g, with the card to add and subtract 1）, agent/d, 150mL oral Decoction, sooner or later. Continuous treatment for 6 months for a course of 1. The clinical symptoms, symptom score, liver function, hepatic fibrosis, color Doppler ultrasonography, liver stiffness and adverse reactions were observed in four cases. Treatment of 1 courses, to determine the efficacy. 18 cases were cured after treatment in the treatment group. [Result] 9 cases were effective, 2 cases ineffective, the total efficiency of 93.10%; control group 12 cases were cured clinically, 8 c.ases were effective, 10 cases ineffective, the total efficiency of 66.67%; the treatment group than the control group （P〈0.05）. Symptom scores, ALT, AST, TBil, ALB, PCIII, LN, HA, IV-C, color Doppler ultrasonography and liver stiffness values in the treatment group were better than those in the control group （P〈0.01）. [Conclusion] Shugan Huayu Decoction Combined with western medicine in the treatment of liver qi stagnation and blood stasis type of hepatic fibrosis, the curative effect is satisfied, no serious adverse reactions, worthy of promotion.
出处
《实用中医内科杂志》
2017年第4期41-44,共4页
Journal of Practical Traditional Chinese Internal Medicine
关键词
肝纤维化
胁痛
黄疸
癥积
肝郁血瘀
疏肝化瘀汤
恩替卡韦
甘草酸二铵
还原型谷胱甘肽
螺内酯
呋噻米
症状积分
ALT
AST
TBil
ALB
PCIII
LN
HA
IV-C
彩色多普勒
门静脉内径
脾静脉内径
脾脏厚度
肝脏硬度
中西医结合治疗
随机平行对照研究
Hepatic fibrosis
chest pain
jaundice
disease product
liver Qi stagnation and blood stasis
Shuganhuayu Decoction
entecavir Cave
diammonium glycyrrhizinate
glutathione
spironolaetone
furosemide
symptom
ALT
AST
TBil
ALB
PCIII
LN
HA
IV-C
color Doppler
the diameter of portal vein and splenic vein
the thickness of spleen diameter
liver
hardness
integrated traditional Chinese and Western medicine therapy
randomized controlled study
