摘要
目的探讨地佐辛和瑞芬太尼在无痛人流中的联合应用。方法选取300例早孕患者,随机均分3组。D组地佐辛0.1mg/kg、F组瑞芬太尼1.5μg/kg、DF组地佐辛0.05 mg/kg和瑞芬太尼0.75μg/kg。观察记录各麻醉时段的SBP、DBP、HR、SPO2变化,以及苏醒时间、呼吸抑制情况等。结果 1 3组患者的SBP和DBP在扩宫时均有下降,D组与F组、DF组比较差异有统计学意义;扩宫时,F组HR及SPO2与D组、DF组比较显著下降,差异有统计学意义;2 F组和DF组的苏醒时间、离院时间及丙泊酚用量与D组比较显著减少,差异有统计学意义;术中呼吸抑制,D组、DF组与F组比较显著减少,差异有统计学意义;3术中麻醉效果,F组和DF组优和差的发生率与D组比较,差异有统计学意义;4术后VAS评分,D组和DF组评分与F组比较,差异有统计学意义。结论地佐辛和瑞芬太尼联合应用,不仅减少了丙泊酚的总用药量,术中和术后镇痛效果确切,缩短苏醒和离院时间,减少毒副作用,提高患者和术者的满意度。
Objective To study the application of dezocine and remifentanil reunite with propofol for painless induced abortion. Methods 300 women in early pregnancy for painless induced abortion were included and were randomly divided into three groups, each group with 100 cases. Dezocine 0. 1mg/kg and propofol were used for patients in group D, remifentanil 1.5ug/kg and propofol were used for patients of group F, Dezocine 0.05mg/kg, remifentanil 0.75ug/kg and propofol were administered for patients in group DE The analgesic effect, SBP, DBP, HR, SPO2 before anesthesia, during the operation and the end of the operation, propofol dosage, operation time, recovery time, hospital stay, body movement, respiratory depression were compared between the three groups. Results ① Patients in group D had significant different SBP and DBP in the expanding palace, while patients in group F had significant different HR and SPO2 in the expanding palace （ P〈0.05 ） ; ② Patients in group F and DF were significandy different in recovery time, hospital time and dosage of propofol with those in group D （ P〈0.05 ） ; Patients in group D and DF had significant differences in the occurrence of respiratory depression with group F （P〈0.05） ; ③ The analgesic effect during operation, the occurrence of excellent and poor of group F and DF was significantly different from group D （ P〈0.05 ） ; ④Postoperative pain VAS of group D and DF was significantly different from group F （ P〈0.05 ） . Conclusion The dezocine and remifentanil combined with propofol for painless induced abortion can reduce the total dosage of propofol, have very good analgesic effect, shorten the time to wake up and hospital stay, reduce side effects, increase satisfaction from patients.
出处
《北京医学》
CAS
2017年第4期371-374,共4页
Beijing Medical Journal
关键词
地佐辛
瑞芬太尼
无痛人流术
dezocine
remifentanil
painless artificial abortion
