摘要
目的分析老年肺结核患者的血清白蛋白(ALB)、血红蛋白(HGB)等相关营养指标,探讨营养不良与老年肺结核疾病的相关性。方法检测2016年1月至6月107例老年(均≥60岁)肺结核患者的血清总蛋白(TP)、ALB、球蛋白(GLB)、白球蛋白比(A/G)、全血红细胞计数(RBC)、血红蛋白(HGB)、淋巴细胞计数、补体3(C3)、C4、C反应蛋白(CRP)水平,了解所有患者相关指标情况。然后根据痰涂片结核分枝杆菌阳性(涂阳)和阴性(涂阴),将患者分为涂阳组和涂阴组,比较两组各营养指标和炎症指标的差异。并对全部患者血清ALB水平和淋巴细胞计数的相关性,以及其和CRP水平的相关性,分别进行Pearson相关性分析。结果 107例老年肺结核患者RBC、HGB、淋巴细胞计数、TP、ALB、GLB、A/G等营养指标均降低,以血清ALB降低率最高,达43.93%。涂阳组ALB、HGB、A/G水平明显低于涂阴组,CRP水平明显高于涂阴组,差异均有统计学意义(P均<0.05)。相关性分析结果显示,老年肺结核患者(包括涂阳、涂阴)血清ALB水平与淋巴细胞计数呈正相关(r=0.297,P<0.05);与CRP水平呈负相关(r=-0.600,P<0.01)。结论老年肺结核患者普遍存在血清ALB降低。ALB、HGB、A/G降低在涂阳患者中更为明显,是疾病进展的高危因素,应积极进行干预。
Objective To analyze the levels of serum albumin （ALB） , hemoglobin （HGB） and some other nutrition inde- xes in elderly patients with pulmonary tuberculosis and investigate the correlations between them and the disease status. Methods Levels of total protein （TP） , ALB, globulin （ GLB ） , ratio of albumin to globulin （ A/C）, red blood cell count （RBC） in whole blood, HGB,lymphocyte count, complement （ C ） 3, C4, C-reactive protein （CRP） in 107 elderly patients with pulmonary tuberculosis were detected to know about the information of relative indexes of the patients. According to sputum smear-positive or negative for mycobacterium tuberculosis, the patients were divided into smear-positive group and smear-negative group, and the nutritional and inflammatory indexes were compared between two groups. Spearman＇s correla- tion analysis was used to analyze the correlations between serum ALB level and lymphocyte count, as well as the correlations between serum ALB level,lymphocyte count and CRP level. Results The nutritional indexes including RBC, HGB, lym- phocyte count,TP, ALB, GLB and A/G in cases of 107 elderly pulmonary tuberculosis decreased in which the incidence of serum ALB reduction was the highest （43.93%）. Levels of ALB, HGB and A/G in smear-positive group were significantly lower than those in smear-negative group, and the level of CRP in smear-positive group was significantly higher than that in smear-negative group（ all P 〈 0.05 ）. Spearman＇s correlation analysis showed that serum ALB level was positively correlated with lymphocyte count（ r = 0.297 ,P 〈 0.05 ） and negatively correlated with CRP level（ r = - 0. 600 ,P 〈 0.01 ） in all elderly pulmonary tuberculosis patients. Conclusions The decrease of ALB in elderly patients with pulmonary tuberculosis univer- sally exists. The decreases of ALB, HGB and A/G in smear-positive patients are more obvious which are the high risk fac- tors of disease progression, and the risk factors should be actively intervened.
出处
《中国临床研究》
CAS
2017年第4期459-462,共4页
Chinese Journal of Clinical Research
基金
2015年安徽省卫计委结核病防治应用课题(15tb001)
关键词
肺结核
老年
痰涂片
结核分枝杆菌
蛋白质
营养科学
Pulmonary tuberculosis
Elderly
Sputum smear
Mycobacterium tuberculosis
Protein
Nutritional science
