摘要
目的探讨幽门螺杆菌(H.pylori)与溃疡性结肠炎(UC)的关系。方法采用病例对照研究,严格按照病例对照的纳入和排除标准选取2014年9月至2016年9月于河南省人民医院消化内科就诊的58例初发型UC患者为病例组,选择同期就诊的80例有消化道症状且肠镜检查无器质性病变或正常结肠表现的患者为对照组,均行^(13)C尿素呼气试验确定有无H.pylori感染。对两组患者的年龄、性别、BMI、受教育年限、吸烟史及H.pylori感染情况进行比较,运用多因素Logistic回归分析UC的影响因素,并比较UC不同病变范围及程度间的H.pylori感染率有无差异。结果病例组与对照组比较,年龄、吸烟史及H.pylori感染情况差异有统计学意义(P<0.05,P<0.01)。多因素Logistic回归分析结果显示,年龄、吸烟史与UC无相关性(P均>0.05);H.pylori感染与UC呈负相关(OR=0.350,95%CI=0.166~0.735,P=0.006)。此外,轻、中、重度UC患者的H.pylori感染率分别为37.50%、31.58%、26.67%,随UC病变程度加重,H.pylori感染率略有下降,但差异无统计学意义(P>0.05);直肠型、左半结肠型及全结肠型UC患者的H.pylori感染率分别为37.50%、31.82%、30.00%,随病变范围的增大,H.pylori感染率略有下降,但差异无统计学意义(P>0.05)。结论 H.pylori感染率与UC的发生呈负相关性,H.pylori感染可能是UC发生的保护性因素,其具体机制有待进一步研究。
Objective To investigate the relationship between Helicobacter pylori （ H. pylori） and ulcerative colitis （UC） Methods A total of 58 patients with primary type UC who visited the department of digestive diseases in Henan Province People＇s Hospital between September 2014 and September 2016 were selected as case group in strict accordance with the inclusion and exclusion criteria of cases and controls, and 80 patients of the same period with digestive tract symptoms but without organic lesions or normal colonic presentation by colonoscopy were selected as control group. 13 C-urea breath test was performed to determine H. pylori infection. Age, sex, body mass index （ BMI ） , years of education, smoking history and status of H. pylofi infection were compared between two groups. Multivariate Logistic regression analysis was performed to analyze the influencing factors in UC. The H. pylori infection rates of different extent lesions and different degree lesions in UC were compared. Results There were statistical differences in age, smoking history and status of H. pylori infection be- tween two groups （P 〈0.05, P 〈 0.01 ）. Logistic regression analysis showed that there were no associations of age and smoking history with UC, but H. pylori infection was negatively correlated with UC （ OR = 0. 350,95 % C1 = 0.166 -0. 735, P =0. 006）. The H. pylofi infection rates in patients with mild, moderate and severe UC were 37.50% ,31.58%, and 26. 67% respectively, namely, H. pylori infection rates decreased with the aggravation of degree of UC lesions, but no signif- icant difference was found in them （ P 〉 0.05 ）. The H. pylori infection rates in UC of the rectum, the left colon and the whole colon were 37.50% ,31.82% and 30.00% respectively, namely, H. pylori infection rates decreased with the increase of scope of UC lesions, but no significant difference was found in them （ P 〉 0.05 ）. Conclusions H. pylori infection rate was negatively correlated with occurrence of UC. H. pylori infection may be a protective factor for occurrence of UC, but its concrete mechanism needs to be further studied.
出处
《中国临床研究》
CAS
2017年第4期447-450,共4页
Chinese Journal of Clinical Research
基金
河南省基础与前沿技术研究计划项目(142300410050)
