摘要
目的分析阿托伐他汀联合曲美他嗪治疗冠心病临床效果。方法方便选取2015年4月—2016年6月在该院就诊的92例冠心病患者,按照数字随机数字表法将患者分为对照组和试验组,每组46例患者;两组患者均行扩血管药、钙拮抗剂、抗血小板聚集、吸氧、利尿剂等常规治疗;对照组在以上治疗基础上给予阿托伐他汀治疗,实验组采用阿托伐他汀联合曲美他嗪治疗;对比分析两组患者临床治疗效果、血脂水平以及心绞痛发作持续时间。结果 (1)对照组中,有9例患者无效,总有效率为80.43%;而实验组中,有3例患者无效,总有效率为93.48%;差异有统计学意义(P<0.05)。(2)在治疗后,两组患者TC、TG、HDL-C和LDL-C血脂水平均显著的低于治疗前(P<0.05);在治疗后实验组TC、TG和LDL-C水平分别为(2.20±0.83)、(1.31±0.13)、(1.48±0.04)mmol/L,下降程度教对照组更为显著(P<0.05)。(3)两组患者在治疗后心绞痛发作持续时间均显著的低于治疗前(P<0.05);治疗后实验组心绞痛发作持续时间为(3.18±0.70)min,显著的低于对照组(4.89±0.89)min(P<0.05)。结论与单独的阿托伐他汀临床用药相比,阿托伐他汀联合曲美他嗪临床效果更好,降低TC、TG和LDL-C血脂水平更为明显,患者心绞痛发作持续时间更短,在临床中具有推广和应用的价值。
Objective To analyze the clinical effect of atorvastatin and trimetazidine in treatment of coronary heart disease.Methods 92 cases of patients with coronary heart disease in our hospital from April 2015 to June 2016 were conveniently selected and randomly divided into two groups with 46 cases in each,both group adopted the routine treatment of vasodilators,calcium antagonists,anti-platelet aggregation,oxygen inhalation and diuretics,the control group were treated with atorvastatin on the basis of the above,while the experimental group were treated with atorvastatin and trimetazidine,and the clinical treatment effect,blood fat level and angina pectoris attacks continuous time were compared between the two groups.Results In the control group,9 cases were ineffective,and the total effective rate was 80.43%;in the experimental group,3cases were ineffective,and the difference in the total effective rate was obvious（P〈0.05）,after treatment,the TC,TG,HDL-C and LDL-C blood fat level of the two groups were obviously lower than those before treatment（P〈0.05）,and the TC,TG and LDL-C levels in the experimental group after treatment were respectively（2.20±0.83）,（1.31±0.13）,（1.48±0.04）mmol/L,and the decrease degree was more obvious than that in the control group,（P〈0.05）,after treatment,the angina pectoris attack duration of the two groups were obviously lower than that before treatment（P〈0.05）,after treatment,the angina pectoris attack duration in the experimental group was obviously lower than that in the control group,[（3.18±0.70）min vs（4.89±0.89）min]（P〈0.05）.Conclusion The clinical effect of atorvastatin and trimetazidine is better than the single atorvastatin,and the effect of decreasing the TC,TG and LDL-C blood fat level is more obvious,and the angina pectoris attack duration is shorter,which is worth promotion and application in clinic.
出处
《中外医疗》
2017年第7期4-6,共3页
China & Foreign Medical Treatment
关键词
冠心病
阿托伐他汀联合曲美他嗪
血脂水平
心绞痛发作持续时间
Coronary heart disease
Atorvastatin and trimetazidine
Blood fat level
Angina pectoris attack duration
