摘要
目的了解肺结核人群中的戊型肝炎(戊肝)流行特征,为更有效地开展肺结核和戊肝防治工作提供科学依据。方法采集2015年10月至2016年9月采集湖北省安陆市173人肺结核患者的血清,进行肝功能、抗-HEV IgG和抗-HEV IgM检测,对抗-HEV IgM阳性样本进行HEV RNA检测,同时收集其人口学资料和其他疾病感染史。结果共调查173例肺结核人群,肺结核人群抗-HEV IgM阳性率为0.58%(1/173),肺结核人群抗-HEV IgG阳性率为38.73%(67/173),HEV RNA未检出。肺结核患者中抗-HEV IgG阳性率与年龄呈线性关系,随年龄增加而增加。肺结核患者有肝功能异常史的戊肝既往感染率较高。肺结核患者中抗-HEV IgG阳性率在性别、肺结核病程长短、区域、职业上分布差异均无统计学意义(P>0.05)。结论活动期的肺结核人群HEV感染不容忽视,积极开展两病双向筛查的同时需采取针对性的预防和治疗措施。
Objective To analyze hepatitis E serum epidemiology in tuberculosis population and provide scientific basis for the control of tuberculosis and HEV.Methods 173 serum samples were collected from October 2015 to September 2016 in Aulu.Anti-HEV IgM positive samples were tested by HEV RNA.Liver function screening,demographic data andother diseases history were collected from 173 TB patients.Results Anti-HEV IgM positive rate was 0.58%（1/173）,and Anti-HEV IgG positive rate was 38.73%（67/173）.No HEV RNA was detected.Anti-HEV IgG positive rate had a linear relationship with age,and increased with age.A higher HEV infection rate was found among the patients with the history of abnormal liver function.Anti-HEV IgG positive rates among pulmonary TB patients had no statistical differences with the following factors：such as gender,length of the course of TB,distribution of regions and occupations.Conclusion HEV infection of active pulmonary TB should not be ignored,actively carrying out two-way screening for the two diseases,and taking targeted prevention and treatment measures were needed.
出处
《公共卫生与预防医学》
2017年第2期35-37,共3页
Journal of Public Health and Preventive Medicine
基金
国家自然基金资助项目(81573239)
湖北省卫生和计划生育委员会面上资助项目(WJ2017M174)(WJ2017M240)
