摘要
目的观察苯磺酸氨氯地平对老年人收缩期高血压的治疗效果,并对其临床疗效及安全性进行总结分析。方法将120例老年收缩期高血压患者纳入此次研究,并按随机数字表法分为观察组和对照组,每组患者60例,对照组给予硝苯地平进行治疗,观察组给予苯磺酸氨氯地平进行治疗,连续治疗4周后,比较两组患者临床疗效及不良反应发生情况。结果两组患者治疗前后收缩压均明显下降,且差异有统计学意义(P<0.05)。观察组和对照组相比,收缩压下降幅度差异不明显,差异无统计学意义(P>0.05);而治疗前后,两组患者舒张压下降不明显,差异无统计学意义(P>0.05)。治疗后,相对于对照组,观察组患者左室舒张早期充盈峰值流速与心房收缩期充盈峰值流速比值(E/A值)、射血分数(EF)、内生肌酐清除率(Ccr)明显提升,但其左室重量指数(LVMI)、尿微量清蛋白(MAU)均明显降低,两组差异有统计学意义(P<0.05)。经治疗后,观察组显效27例,有效20例,无效13例,总有效率高达78.33%;对照组显效28例,有效17例,无效15例,总有效率为76.67%。两组降压效果均明显,但总有效率相比,差异无统计学意义(P>0.05)。两组不良反应的发生率差异无统计学意义(P>0.05)。结论苯磺酸氨氯地平治疗老年收缩期高血压效果确切。
Objective To observe the effect of amlodipine besylate on the treatment of systolic hypertension in the elderly. Methods 120 elderly patients with systolic hypertension were included in this study, according to the ran-dom number table method, the patients were divided into observation group and control group, with 60 cases in each group,the control group was given nifedipine treatment,the observation group was given amlodipine besylate treatment, after 4 weeks of continuous treatment, compare with two groups of patients with clinical efficacy and adverse reactions oc-cur. Results Systolic blood pressure in both groups were significantly decreased after treatment, and difference was sta-tistically significant （ P 〈 0. 05 ） , compared with observation group and control group, the systolic pressure drop differ-ence is not obvious, there was no statistical significance （P 〉 0. 05 ） ;And around treatment, the two groups of patients with diastolic pressure drop was not obvious, there was no statistical significance （ P 〉0. 05 ） . After treatment compared with the control group, the EF, E/A and Ccr in the observation group were significantly improved, but the LVMI and MAU were significantly lower, the difference between the two groups was statistically significant. After treatment, there were 27 cases were markedly improved,20 cases weie effective, 13 cases of invalid in the observation group,the total ef-fective rate up to 78. 33% ;there were 28 cases had marked effect, 17 cases effective, 15 cases were invalid in control group,the total effective rate was 76. 67% . Two groups of antihypertensive effect was obvious,but the total effective rate compared to no significant statistical difference （P 〉0. 05）. The incidence of adverse reactions were also no significant difference between two groups （P 〉0. 05） . Conclusion The effect of amlodipine besylate in the treatment of elderlypatients with systolic hypertension, it is worthy of clinical application.
出处
《中国临床保健杂志》
CAS
2017年第2期146-148,共3页
Chinese Journal of Clinical Healthcare
