摘要
Dear Editor, Acute promyelocytic leukemia （APL） caused by the malig- nant proliferation of bone marrow-derived cells, which is driven by the chromosomal translocation, leading to the fusion of the promyelocytic leukemia gene （PML） and the retinoic acid receptor-a gene （RARA） （de The et al., 1990; Goto et al., 2011）. The oncogenic protein PML-RARA has been found specifically in more than 95% APL patients and is crucial for both the pathogenesis and therapeutics of APL （de The et al., 1990; Zhou et al., 2007; Wang and Chen, 2008）. Arsenic trioxide （AS203）, an ancient traditional Chi- nese medicine, has recently been adopted as the first-line treatment for APL patients by the National Comprehensive Cancer Network （Wang and Chen, 2008; Zhu and Huang,
Dear Editor, Acute promyelocytic leukemia （APL） caused by the malig- nant proliferation of bone marrow-derived cells, which is driven by the chromosomal translocation, leading to the fusion of the promyelocytic leukemia gene （PML） and the retinoic acid receptor-a gene （RARA） （de The et al., 1990; Goto et al., 2011）. The oncogenic protein PML-RARA has been found specifically in more than 95% APL patients and is crucial for both the pathogenesis and therapeutics of APL （de The et al., 1990; Zhou et al., 2007; Wang and Chen, 2008）. Arsenic trioxide （AS203）, an ancient traditional Chi- nese medicine, has recently been adopted as the first-line treatment for APL patients by the National Comprehensive Cancer Network （Wang and Chen, 2008; Zhu and Huang,
