摘要
目的观察奥替溴铵联合氟哌噻吨美利曲辛治疗肠易激综合征的疗效及其对血清炎性因子的影响。方法将2013年2月至2016年2月在柘城县人民医院治疗的102例肠易激综合征患者分为观察组和对照组,每组51例。在常规治疗的基础上,对照组患者采用奥替溴铵治疗,观察组患者在对照组治疗基础上加服氟哌噻吨美利曲辛。采用酶联免疫吸附法检测2组患者治疗前后血清炎性因子白细胞介素-6(IL-6)、IL-8水平,并比较2组患者的治疗效果和不良反应。结果观察组患者治疗总有效率为92.16%(47/51),显著高于对照组的70.59%(36/51)(χ2=7.826,P<0.05)。2组患者治疗前血清IL-6、IL-8水平比较差异无统计学意义(P>0.05);治疗后,2组患者血清IL-6、IL-8水平均较治疗前降低(P<0.05),且观察组患者血清IL-6、IL-8水平较对照组下降更显著(P<0.05)。对照组患者不良反应发生率为7.84%(4/51),与观察组患者不良反应发生率3.92%(2/51)比较差异无统计学意义(χ2=0.708,P>0.05)。结论奥替溴铵联合氟哌噻吨美利曲辛治疗肠易激综合征临床疗效优于单用奥替溴铵,并可显著降低血清炎性因子水平。
Objective To observe the therapeutic effect of otilonium bromide combined with flupentixol and melitracen for treatment of the irritable bowel syndrome（IBS） and its influence on serum inflammatory factors. Methods One hundred and two patients with IBS in the People＇s Hospital of Zhecheng County from February 2013 to February 2016 were divided into observation group （ n = 51 ） and control group （ n = 51 ）. All patients were given routine treatment. Based on this, the patients in control group were given otilonium bromide;and the patients in observation group were given otilonium bromide and flupentixol and melitracen. The serum levels of inflammatory eytokines including interleukin-6 （ IL-6 ） and interleukin-8 （ IL-8 ） were detected by enzyme linked immunosorbent assay in the two groups before and after treatment. The therapeutic effect and inciderce of adverse reactions were compared between the two groups. Results The total effective rate of patients in observation group （92.16% ,47/51 ） was significantly higher than that in the control group （ 70.59% , 36/51 ） （X2 = 7. 826, P 〈 0.05 ）. There was no statistic difference in the levels of IL-6 and IL-8 between the two groups before treatment （ P 〉 0.05 ） ; the levels of IL- 6 and IL-8 in the two groups after treatment were lower than those before treatment （ P 〈 0.05 ） , and the levels of 1L-6 and IL- 8 in observation group decreased significantly than the control group （ P 〈 0.05 ）. The incidence of adverse reaction in the control group and the observation group was 7.84% （4/51 ） and 3.92% （2/51 ） respectively;there was no significant difference in the incidence of adverse reaction between the two groups （X2 = 0.708,P 〉 0.05）. Conclusion The therapeutic effect of otilonium bromide combined with flupentixol and melitracen for treatment of the IBS is better than otilonium bromide, and can significantly decrease the levels of serum inflammatory factors.
出处
《新乡医学院学报》
CAS
2017年第3期203-205,共3页
Journal of Xinxiang Medical University
关键词
奥替溴铵
氟哌噻吨美利曲辛
肠易激综合征
血清炎性因子
otilonium bromide
flupentixol and melitracen
irritable bowel syndrome
serum inflammatory factors
