摘要
目的探讨肝脏超声造影术对肝癌实时引导下射频消融(RFA)治疗的临床应用价值。方法选取行肝癌射频消融治疗的110例肝癌病人,对比观察应用常规彩超引导的51个病灶和超声造影技术(CEUS)实时引导下的59个病灶进行射频消融前后的临床疗效。结果对110例肝癌病灶超声实时引导下的RFA均成功,无术后出血、肝脓肿、胆漏、针道转移、皮肤灼伤等并发症。以术后1个月行肝脏增强CT为检查标准,常规超声引导下的51个病灶一次性完全消融36个,完全消融率达70.6%,超声造影引导下的59个病灶完全消融54个,完全消融率达91.5%,两种引导方法的病灶完全消融率差异有统计学意义(χ~2=8.06,P=0.005)。多因素非条件Logistic回归分析结果表明,超声造影引导方法是疗效的保护性因素,OR(95%CI):5.051(1.619~15.757),P=0.005。结论超声造影引导下的RFA治疗效果优于常规超声引导的RFA。
Objective To evaluate the application value of contrast-enhanced ultrasound （CEUS） in the radiofrequency ablation（RFA） of hepatocellular carcinoma （ HCC）. Methods 110 HCC patients treated by radiofrequency ablation were selected in the secord affiliated hospital of Anhui medical university. The RFA of hepatic carcinoma lesion was guided by conventional color ultrasound and CEUS. The rates of postoperative complete ablation were compared between the 51 lesions guided by conventional color ultrasound and the 59 lesions guided by CEUS. Results All the 110 case of contrast-enhanced ultrasound （ CEUS） in RFA of HCC were success, which there are no complications such as postoperative bleeding,hepatapostema,bile leak,Needle metastasize. One month after opera-tions ,taken enhanced CT examination as standard, the complete ablation rate of RFA guided by conventional color ultrasound was 70. 6%. The complete ablation rate of RFA guided by the CEUS was 91.5%. The comparison of complete ablation rates of lesions a-mong 2 methods of imaging examination showed that the difference was statistically significant （X2= 8. 06 = 0. 005 ） . Multi-factor un-conditioned logistic regression analysis show that the RFA guided by CEUS is the only protective factors, OR （95% CI） ： 5. 051 （ 1 .619-15. 757） ,P =0. 006. Conclusion CEUS can significantly improve the operation effect in radiofrequency ablation for HCC.
出处
《安徽医药》
CAS
2017年第2期290-293,共4页
Anhui Medical and Pharmaceutical Journal
基金
安徽省自然科学基金(1608085MH164)
关键词
超声造影
射频消融
肝细胞癌
彩色超声
Contrast-enhanced ultrasound
Radiofrequency ablation
Hepatocellular carcinoma
Color ultrasound
