摘要
目的比较单磷酸阿糖腺苷与利巴韦林治疗手足口病(HFMD)患儿的效果。方法将某院2013年4月—2015年4月收治的120例HFMD患儿随机分为观察组和对照组,每组60例,观察组采用单磷酸阿糖腺苷进行治疗,对照组采用利巴韦林进行治疗,比较两组患儿疗效。结果治疗后观察组肠道病毒EV、EV71、柯萨奇病毒A16(CA16)的病毒转阴率分别为87.0%、85.7%、93.1%,对照组分别为64.0%、69.8%、78.6%,两组比较,差异均有统计学意义(均P<0.05)。观察组患儿住院时间为(4.5±1.3)d,短于对照组的(6.2±1.2)d;各症状(发热、口腔炎、皮疹)控制时间均短于对照组(均P<0.05)。按有无合并症进行分组,观察组的治疗效果均优于对照组;治疗后观察组患儿心肌酶谱各项指标、C反应蛋白(CRP)、WBC均低于对照组(均P<0.05)。结论单磷酸阿糖腺苷治疗组HFMD患儿疗效优于利巴韦林对照组,但需进一步研究。
Objective To compare the efficacy of vidarabine monophosphate and ribavirin for treating hand-footmouth disease（HFMD）in children.Methods 120 children with HFMD and admitted to a hospital from April 2013 to April 2015 were randomly divided into observation group and control group,60 cases in each group,observation group treated with vidarabine monophosphate,control group treated with ribavirin,the therapeutic efficacy between two groups were compared.Results After treatment,the negative conversion rate of intestinal virus EV and EV71,as well as Coxsackie virus A16（CA16）in observation group were 87.0%,85.7%,and 93.1%respectively,in control group were 64.0%,69.8%,and 78.6% respectively,difference between two groups was statistically significant（all P〈0.05）.The average length of hospital stay in observation group was shorter than control group（[4.5± 1.3]days vs[6.2 ± 1.2]days,P〈0.05）,symptom（fever,stomatitis,skin rash）control time in observation group were all shorter than control group（all P〈0.05）.Whether patients with or without complication,therapeutic effect of the observation group was better than that of control group;myocardial enzyme data,C reactive protein（CRP）,and white blood cell（WBC）in observation group were all lower than control group（all P〈0.05）.Conclusion Efficacy of vidarabine monophosphate for treating children with HFMD is better than ribavirin,but it needs further study.
出处
《中国感染控制杂志》
CAS
北大核心
2017年第3期263-266,共4页
Chinese Journal of Infection Control
关键词
单磷酸阿糖腺苷
利巴韦林
手足口病
vidarabine monophosphate
ribavirin
hand-foot-mouth disease
