摘要
目的对连翘Forsythia suspensa的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果从连翘的50%乙醇提取物中分离得到了13个化合物,分别鉴定为毛柳苷(1)、连翘酯苷E(2)、quinolacetic acid(3)、黄瑞烷酮(4)、千里光内酯(5)、cleroindicin C(6)、4-羟基-4-异丙基-1-环己烯甲酸(7)、oleuropeic acid(8)、rel-(1S,2S,4S)-trihydroxy-p-menthane(9)、壬二酸(10)、2-羟基-丁二酸-4-内酯(11)、glochidioboside(12)、(+)-异落叶松脂醇-9-O-β-D-葡萄糖苷(13)。结论化合物5~13为从连翘属中首次分离得到。
Objective To study the chemical constituents from the fruits of Forsythia suspensa. Methods Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. Results Thirteen compounds were isolated and identified as salidroside （1）, forsythoside E （2）, quinolacetic acid （3）, rengyolone （4）, senecio lactone （5）, cleroindicin C （6）, 4-hydroxy-4-isopropylcyclohex-1-enecarboxylic acid （7）, oleuropeic acid （8）, rel-（1S,2S,4S）-trihydroxy-p-menthane （9）, azelaic acid （10）, 2-hydroxy-succinic acid 4-methylester （11）, glochidioboside （12）, and （＋）-isolariciresino-9-O-β-D-glucopyranoside （13）. Conclusion Compounds 5-13 are isolated from genus Forsythia Vahl. for the first time.
作者
阎新佳
温静
项峥
杨波
吴健
江培
崔琳琳
赵瑛
YAN Xin-jia WEN Jing XIANG Zheng YANG Bo WU Jian JIANG Pei CUI Lin-lin ZHAO Ying(College of Pharmacy, Harbin University of Commerce, Harbin 150076, China Center of Research on Life Science and Environmental Science, Harbin University of Commerce, Harbin 150076, China)
出处
《中草药》
CAS
CSCD
北大核心
2017年第4期644-647,共4页
Chinese Traditional and Herbal Drugs
基金
2016年哈尔滨商业大学研究团队支持项目(2016TD009)
2016年哈尔滨商业大学青年创新人才支持项目(2016QN074)
