摘要
目的:研究血清补体C3及C4水平与慢性乙肝(CHB)患者肝炎分级程度及肝纤维化程度的关系。方法:收集2014年3月~2016年3月期间,我院收治的CHB患者185例作为CHB组,同期体检健康者60例作为对照组,检测并比较两组的血清补体C3、C4水平,并分析C3、C4与CHB肝炎G分级、肝纤维化S分级的关系。结果:CHB组的血清C3、C4水平显著低于对照组(t=10.476、9.172,P<0.05);血清C3、C4水平在不同肝炎活动度之间比较差异显著(F=4.321、3.495,P<0.05),在不同肝纤维化分级之间比较差异显著(F=3.861、4.541,P<0.05);血清C3、C4水平与肝炎活动度G分级呈显著负相关性(r=-0.575、-0.542,P<0.05),与肝纤维化S分级(≥S1)显著负相关性(r=-0.512、-0.636,P<0.05)。结论:血清补体C3、C4水平与CHB患者肝炎程度及肝纤维化程度密切相关,可作为CHB患者肝病理学状态的辅助预测指标。
Objective： To investigate the relationship between serum complement C3,C4 and hepatitis grade level and liver fibrosis degree in patients with chronic hepatitis B（ CHB）. Methods： 185 cases of patients with CHB admitted in our hospital from March 2014 to 2016 March were collected as CHB group,60 cases who were considered healthy at the same period as the control group. The serum complement C3,C4 of the two groups were detected and compared,and relationship between serum complement C3,C4 and hepatitis grade level and liver fibrosis degree was analyzed. Results： The serum C3,C4 levels in CHB group were significantly lower than the control group（ t = 10. 476,9. 172,P〈0. 05）. The differences of serum C3,C4 levels among different levels of hepatitis activity were significant（ F = 4. 321,3. 495,P〈0. 05）,and differences among different levels of hepatic fibrosis grading were significant（ F=3. 861,4. 541,P〈0. 05）. The serum C3,C4 levels were negatively associated with G rating of hepatitis activity（ r =-0. 575,-0. 542,P〈0. 05）,and were negatively associated with S rating（ ≥S1） of liver fibrosis（ r =-0. 512,-0. 636,P〈0. 05）. Conclusion：The serum complement C3,C4 levels is closely related with hepatitis grade level and liver fibrosis degree in patients with CHB,it can be used as secondary predictors of hepatic pathological status in CHB patients.
作者
郭飞波
GUO Fei-Bo(Department of Clinical Laboratory, Tianmen First People＇s Hospital, Tianmen 431700 ,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2017年第3期426-428,432,共4页
Chinese Journal of Immunology
关键词
慢性乙型肝炎
肝纤维化
肝炎炎症分级
补体
Chronic hepatitis B
Liver fibrosis
Hepatic inflammation grade
Complement
