摘要
目的探讨慢性精神分裂症患者血清超敏C反应蛋白(hs-CRP)、总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)比值与精神症状的关系。方法检测65例精神分裂症患者(患者组)和62例同期健康体检者(健康对照组)血清hs-CRP、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,并计算TC/HDL-C比值;阳性和阴性症状量表(PANSS)评定患者入组时的精神症状。结果患者组血清hs-CRP水平[(2.87±0.75)mg/L]显著高于健康对照组[(0.96±0.25)mg/L],患者组血清TC水平[(1.93±0.51)mmol/L]显著低于健康对照组[(3.97±1.15)mg/L],患者组血清HDL-C水平[(1.08±0.33)mmol/L]显著低于健康对照组[(1.74±0.42)mg/L],差异均有统计学意义(P<0.05);患者组血清TC/HDL-C比值(1.78±0.59)显著低于健康对照组的(2.28±0.61)(P=0.028)。相关性分析显示,患者组血清TC/HDL-C比值与阳性症状呈负相关(r=-0.34,P=0.004),患者组血清hs-CRP水平与阳性症状呈正相关(r=0.31,P=0.010)。结论血脂和炎性反应与精神分裂症有密切关系,联合hs-CRP、TC/HDL-C比值的检测有利于预测精神分裂症的发生,可以作为精神分裂症的危险因素。
Objective To investigate the relation between serum levels of high sensitivity CRP（hs-CRP）and total cholesterol/high density lipoprotein cholesterol（TC/HDL-C）with mental symptoms in patients with chronic schizophrenics.Methods Serum hs-CRP,TC and HDL-C were measured in 65 patients with schizophrenia（schizophrenia group）and contemporaneous62 individuals undergoing healthy physical examination（healthy control group）.The ratio of TC/HDL-C was calculated;the Positive and Negative Syndrome Scale（PANSS）was used to assess the mental symptoms of the patients.Results The level of serum hsCRP in the schizophrenia group was（2.87±0.75）mg/L,which was significantly higher than（0.96±0.25）mg/L in the healthy control group;the level of serum TC in the schizophrenia group was（1.93±0.51）mmol/L,which was significant lower than（3.97±1.15）mg/L in the healthy control group;the level of serum HDL-C in the schizophrenia group was（1.08±0.33）mmol/L,which was significant lower than（1.74±0.42）mg/L in the healthy control group,the differences were statistically significant（P〈0.05）;the ratio value of TC/HDL-C in the schizophrenia group was 1.78±0.59,which was significantly lower than 2.28±0.61 in the healthy control group（P=0.028）.The correlation analysis showed that serum TC/HDL-C ratio value was negatively correlated with the positive symptoms（r=-0.34,P=0.004）,while the serum hs-CRP level was positively correlated with the positive symptoms（r=0.31,P=0.010）.Conclusion There is close relationship between inflammation reaction and serum lipid with schizophrenia.The combined detection of TC/HDL-C and hs-CRP is conducive to predict the occurrence of schizophrenia and can be used as the risk factors of schizophrenia.
出处
《检验医学与临床》
CAS
2017年第6期747-748,751,共3页
Laboratory Medicine and Clinic
基金
国家自然科学基金资助项目(81572069)
