摘要
目的探讨不同程度手足口病患儿血清细胞因子及免疫球蛋白水平的变化。方法将2015年6月至2016年6月该院收治的手足口病患儿84例纳入该研究,据临床病情程度将上述患儿分为普通组46例和重症组38例。另选取同期于该院体检的健康幼儿35例作为对照组,检测并比较各组血清细胞因子的水平,主要包括白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)以及免疫球蛋白(IgA、IgG、IgM)。结果重症组的IL-6、IL-10、TNF-α水平分别为(61.81±20.17)ng/L、(174.25±60.41)ng/L、(469.33±168.23)ng/L,均高于普通组和对照组(P<0.05);普通组的IL-6、IL-10、TNF-α水平分别为(15.75±3.41)ng/L、(33.80±12.11)ng/L、(78.22±58.57)ng/L,高于对照组,但差异无统计学意义(P>0.05);重症组的IgA、IgG、IgM水平分别为(0.82±0.26)g/L、(6.87±1.38)g/L、(0.76±0.15)g/L,普通组的IgA、IgG、IgM水平分别为(1.10±0.29)g/L、(8.26±1.05)g/L、(1.12±0.22)g/L,重症组与普通组的免疫球蛋白水平均低于对照组(P<0.05),重症组的免疫球蛋白水平均低于普通组,差异有统计学意义(P<0.05)。结论手足口病患儿存在细胞因子失衡及免疫功能降低且以重症患儿最为明显,采用细胞因子及体液免疫检测有助于临床判断病情。
Objective To investigate the changes of serum cytokines and immunoglobulin levels in children patients with different degrees of hand-foot-mouth disease（HFMD）.Methods Eighty-four cases of HFMD in our hospital from June 2015 to June2016were selected and divided into the common group（46cases）and severe group（38cases）according to the disease condition.Other 35 healthy children undergoing physical examination were selected as the control group.The levels of serum cytokines IL-6,IL-10,TNF-α,IgG,IgM and IgA were detected and the detection results were compared among various groups.Results The levels of IL-6,IL-10 and TNF-αin the severe group were（61.81±20.17）ng/L,（174.25±60.41）ng/L and（469.33±168.23）ng/L respectively which were significantly higher than those in the common group and control group,the differences were statistically significant（P〈0.05）;the levels of IL-6,IL-10 and TNF-in the common group were（15.75±3.41）ng/L,（33.80±12.11）ng/L and（78.22±58.57）ng/L respectively,which were higher than those in the control group,but the difference was not statistically significant（P〉0.05）;the levels of IgA,IgG and IgM in the severe group were（0.82±0.26）g/L,（6.87±1.38）g/L and（0.76±0.15）g/L respectively,which in the common group were（1.10±0.29）g/L,（8.26±1.05）g/L and（1.12±0.22）g/L respectively,which in these two groups were lower than those in the control group,and the immunoglobulin levels in the severe group were lower than those in the common group,the differences were statistically significant（P〈0.05）.Conclusion Children patients with HFMD have the cytokines imbalance and immune function decrease,which in the patients with severe HFMD is most significant,adopting the cytokine and humoral immune detection is helpful to clinically judge the disease condition.
出处
《国际检验医学杂志》
CAS
2017年第6期799-800,804,共3页
International Journal of Laboratory Medicine
关键词
手足口病
细胞因子
免疫球蛋白
hand-foot-mouth disease
cytokines
immunoglobulin
