摘要
目的:探讨胺碘酮治疗老年心律失常的临床效果,并研究其安全性。方法:选取2014年6月-2015年6月在本院住院治疗的心律失常患者126例,按照随机数字表法均分为对照组和观察组,每组63例。对照组采用传统的综合治疗方法,观察组采用传统的综合治疗和胺碘酮联合治疗方法,观察两组的临床疗效、左房内径、心率恢复时间、心房颤动持续时间、心律变异性指标、心功能改善总有效率和不良反应发生率。结果:观察组心律失常改善总有效率明显高于对照组(P<0.05);治疗前两组左房内径、心房颤动持续时间比较,差异均无统计学意义(P>0.05),治疗后观察组左房内径、心房颤动持续时间和心率恢复时间均明显短与对照组(P<0.05);治疗前,两组心律变异性指标(SDNN、RMSSD、PNN50)比较,差异均无统计学意义(P>0.05),治疗后观察组上述指标均优于对照组(P<0.05);两组心功能改善总有效率比较,观察组明显高于对照组(P<0.05);治疗期间两组均有不良反应产生,但差异无统计学意义(P>0.05)。结论:胺碘酮是一种非常有治疗效果的抗心律失常药物,其不良反应小,安全有效,对直流电转复后的心房颤动/心房扑动患者的窦律维持效果较好,在治疗和预防心房颤动、心房扑动、室性心动过速、心室颤动等疗效肯定,且有利于改善预后,故胺碘酮是目前已被证实的降低心律失常病死率和并发症较好的广泛应用药物,值得临床推广使用。
Objective： To investigate the effect of Amiodarone in the treatment of senile cardiac arrhythmias, and to study its security.Method： From June 2014 to June 2015 hospitalized in our hospital treatment of 126 patients with cardiac arrhythmias were selected, they were randomly divided into the control group and the observation group, 63 patients in each group.The control group was given traditional comprehensive treatment, the observation group was giventhe traditional and Amiodarone combined treatment method, the clinical effects, left atrial diameter, heart rate recovery time and duration of atrial fibrillation ,heart rate variability index, heart function to improve the total effective rate and incidence of adverse reactions of two groups were compared.Result： The arrhythmia improve the total effective rate of the observation group was obviously higher than that of the control group （P〈0.05） .Before treatment, left atrial diameter, the duration of atrial fibrillation of two groups had no obvious differences （ P〉0.05 ）, after treatment, left atrial diameter, the duration of atrial fibrillation and heart rate recovery time of the observation group were significantly shorter than those of the control group （P〈0.05） .Before the treatment, there were no obvious differences on heart rate variability index （ SDNN, RMSSD, PNNS0 ） of two groups （ P〉0.05 ）, after treatment, SDNN, RMSSD, PNNS0 of the observation group were better than those of the control group （ P〈0.05 ） .The cardiac function improvement of total effective rate of the observation group was significantly higher than that of the control group （ P〈0.05 ） .Two groups had adverse side effects during the treatment, but there was no statistically significant diffierence （ P〉0.05 ） . Conclusion： Amiodarone is a very the treatment effect of anti-arrhythmic drugs, the treatment of arrhythmia, less adverse reaction is safe and effective, to direct current （ dc ） after converting af/it is better to save the patient＇s DouLv maintain, in the treatment and prevention of atrial fibrillation, atrial flutter, curative effect on ventricular tachycardia and ventricular fibrillation, and to improve prognosis, so Amiodarone is proven to reduce arrhythmia case fatality rate and complication of better widely used drugs, it is worthy of clinical using.
作者
谢佰华
XIE Bai-hua.(The Fourth People＇s Hospital in Nanhai District of Yoshan City, Yoshan 528211, China)
出处
《中国医学创新》
CAS
2017年第8期109-112,共4页
Medical Innovation of China
关键词
胺碘酮
老年心律失常
心房颤动
并发症
Amiodarone
Elderly arrhythmia
Atrial fibrillation
Complication
