摘要
目的探讨老年糖尿病患者合并感染后胰岛素泵强化治疗的有效性,为老年糖尿病合并感染患者的治疗提供参考。方法选取2016年1月1日-6月30日诊治100例老年糖尿病合并感染患者,随机分为对照组与观察组,每组50例,观察组给胰岛素泵强化治疗,对照组常规胰岛素强化皮下注射治疗,观察两组患者治疗前、治疗3d时血糖(FPG、2hPG)、炎性因子(WBC、CRP、PCT)变化,以及治疗后血糖达标时间、胰岛素日用量、感染控制时间、低血糖发生情况。结果两组患者FPG、2hPG、WBC、CRP、PCT治疗后较治疗前明显下降(P<0.05),观察组指标低于对照组(P<0.05);观察组血糖达标时间、胰岛素日用量、感染控制时间分别为(4.75±2.22)d、(34.67±5.31)U/d、(5.61±2.04)d短于对照组(6.43±2.76)d、(42.94±6.65)U/d、(7.67±2.20)d,差异有统计学意义(P<0.05);对照组有8例低血糖发生,观察组有1例低血糖发生,差异有统计学意义(P<0.05)。结论老年糖尿病合并感染患者给予胰岛素泵强化治疗利于感染及血糖水平的及时控制,减少胰岛素用量,降低低血糖发生,是老年糖尿病合并感染时安全、有效的治疗方法。
OBJECTIVE To explore the effectiveness of insulin pump intensive therapy in elderly diabetic mellitus patients complicated with infections so as to provide guidance for treatment of the elderly diabetic mellitus patients complicated with infections. METHODS A total of 100 elderly diabetic me!litus patients complicated with infections who were treated in the hospital from Jan 1, 2016 to Jun 30, 2016 were enrolled in the study and randomly divided into the control group and the observation group, with 50 cases in each group. The observation group was given insulin pump intensive therapy, while the control group was treated with conventional insulin enhanced subcutane- ous injection therapy. The changes of blood glucose （ FPG, 2h PG） and inflammatory factors （WBC, CRP, and PCT） of the two groups of patients were observed before the treatment and after the treatment for 3 days. The blood glucose recovering time, daily dosage of insulin, time of control of infection, and incidence of hypoglycemia were observed after the treatment. RESULTS The levels of FPG, 2h PG, WBC, CRP, and PCT of the two groups of patients were significantly lower after the treatment than before the treatment （P〈0.05）; the indexes of the observation group were significantly lower than those of the control group （P〈0.05）. The blood glucose recove- ring time of the observation group was （4.75±2.22） days, shorter than （6.43±2.76） days of the control group; the daily dosage of insulin of the observation group was （34.67±5.31）U/d, less than （42.94±6.65）U/d of the control group; the time of control of infection of the observation group was （5.61± 2.04） days, shorter than （7. 67±2.20） days of the control group, and there was significant difference （P〈0.05）. Totally 8 cases had hypo- glycemia in the control group, 1 case in the observation group, and there was significant difference （P〈0. 05）.CONCLUSION The insulin pump intensive therapy may facilitate the control of infection and blood glucose level of the elderly diabetic mellitus patients complicated with infection, cut the dosage of insulin, and reduce the incidence of hypoglycemia. It is a safe and effective therapy for the elderly diabetic mellitus patients complicated with infection.
作者
戴慧芳
苏小游
吴朝明
李海
朱烈烈
DAI Hui-fang SU Xiao-you WU Zhao-ming LI Hai ZHU Lie-lie(The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou , Zhejiang 325027, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第5期1050-1053,共4页
Chinese Journal of Nosocomiology
基金
浙江省自然科学基金资助项目(LY15H070003)
关键词
糖尿病
感染
老年
胰岛素泵
强化治疗
Diabetic mellitus
Infection
Elderly
Insulin pump
Intensive therapy
