摘要
目的观察以雷贝拉唑联合黄连素为基础组成新四联疗法作为初始方案对消化性溃疡患者幽门螺杆菌(H.pylori)感染的根除效果及安全性。方法选取2015年5月~2016年10月在湘东区人民医院消化内科诊断伴有Hp感染的消化性溃疡患者共140例,进行抗Hp四联14d疗法初次根除治疗。随机将其中140例消化性溃疡Hp感染患者分为两组,观察组予雷贝拉唑+胶体果胶铋+阿莫西林+黄连素,疗程14d。对照组予奧美拉唑+胶体果胶铋+阿莫西林+克林霉素,疗程14d。患者在疗程结束后1个月进行^(14)C尿素呼气试验检测Hp。结果观察组治疗总有效率为97.14%,显著高于对照组的81.43%,差异有统计学意义(P<0.05);观察组的Hp根除率为97.14%,显著高于对照组的88.57%,差异有统计学意义(P<0.05);观察组不良反应发生率为7.14%,显著低于对照组的18.57%,差异有统计学意义(P<0.05)。结论雷贝拉唑联合黄连素为基础组成新四联14d疗法作为初始方案对初次治疗消化性溃疡患者的Hp感染均能获得较好的根除效果,具有较好的耐受性和临床安全性。
Objective To observe the effect and safety of rabeprazole combined with berberine as the basis of the new quadri-combination therapy in the treatment of H.pylori infection in the patients with peptic ulcer as the initial regimen.Methods A total of 140 patients with peptic ulcer who were diagnosed of being complicated with Hp infection in the Department of Gastroenterology in Xiangdong District People＇s Hospital from May 2015 to October 2016 were selected.They were given 14-day anti-Hp quadri-combination therapy for initial eradication.140 patients with peptic ulcer complicated with Hp infection were randomly assigned to two groups.The observation group was treated with rabeprazole＋bismuthi pectinum colloidale＋amoxicillin＋berberine for a course of treatment of 14 days.The control group was treated with omeprazole＋bismuthi pectinum colloidale ＋amoxicillin ＋clindamycin for a course of treatment of 14 days.Patients were followed by a ^（14）C urea breath test at the end of the course of treatment to detect Hp.Results The total effective rate was 97.14%in the observation group,significantly higher than that of 81.43%in the control group,the difference was statistically significant（P〈0.05）;The eradication rate of Hp in the observation group was 97.14%,which was significantly higher than that of 88.57%in the control group,the difference was statistically significant（P〈0.05）.The adverse reaction rate was 7.14%in the observation group,significantly lower than that of 18.57%in the control group,the difference was statistically significant（P〈0.05）.Conclusion Rabeprazole combined with berberine as the basis of the 14-day new quadri-combination therapy has a favorable eradication effect as the initial regimen on Hp infection in the patients with peptic ulcer who are given the therapy for the first time,with good tolerance and clinical safety.
出处
《中国现代医生》
2017年第1期94-97,共4页
China Modern Doctor
基金
江西省萍乡市医药卫生计生新技术项目[萍卫科教字2016(23)字135-26]
关键词
雷贝拉唑
黄连素
幽门螺杆菌
四联疗法
消化性溃疡
Rabeprazole
Berberine
Helicobacter pylori
Quadri-combination therapy
Peptic ulcer
