摘要
目的探讨妊娠期甲减产妇分娩前后TSH浓度及分娩结局情况。方法选取我院2015年1月~2016年1月收治的妊娠期甲减产妇90例,作为观察组;另选取于我院行妊娠期检查的的健康妊娠期产妇90例,作为对照组。测定两组妇孕早期、孕中期、孕晚期及产后TSH浓度水平,观察并比较两组产妇的分娩结果及产科并发症发生情况。结果两组患者孕早期、孕中期、孕晚期、产后TSH浓度组间比较、多时间点比较、组间。多时间点比较均有明显差异(F=11.51,P=0.003;F=4.74,P=0.030;F=5.46,P=0.020),且观察组患者产后TSH浓度明显高于对照组患者,差异有统计学意义(t=8.12,P<0.05)。对照组患者剖宫产、早产、自发性流产、围生儿死亡率分别为43.33%、4.44%、3.33%、1.11%,观察组患者剖宫产、早产、自发性流产、围生儿死亡率分别为63.33%、16.67%、14.44%、2.22%,对照组患者产后结局明显优于观察组患者,差异有统计学意义(P<0.05)。观察组产科总并发症发生率明显高于对照组,差异有统计学意义(χ~2=11.45,P<0.05)。两组新生儿出生体重、身长、1 min Apgar评分差异明显,对照组新生儿出生情况明显优于观察组,差异有统计学意义(P<0.05)。结论妊娠期甲减妊娠期产妇以及新生儿健康影响巨大,应引起重视,提倡产前对甲减进行筛查。
Objective To investigate and analyze the TSH concentration and delivery outcome of pregnant women with hypothyroidism before and after delivery.Methods A total of 90 cases of pregnant women with hypothyroidism who were treated in our hospital from January 2015 to January 2016 were selected as the observation group;in addition,90 healthy pregnant women who were given pregnancy examination in our hospital were selected as the control group.The levels of TSH in the two groups during first trimester,second trimester and third trimester and after delivery were measured.The results of delivery and obstetric complications were observed and compared between the two groups.Results There were significant differences in TSH concentrations between the two groups,repetitious points between-group and repetitions points（F=11.51,P=0.003;F=4.74,P=0.030;F=5.46,P=0.020）.The TSH concentration after delivery in the observation group was significantly higher than that in the control group,there was statistically significant（t=8.12,P〈0.05）.The rates of cesarean section,premature delivery,spontaneous abortion and perinatal mortality in the control group were 43.33%,4.44%,3.33%,1.11%.The rates of cesarean section,premature delivery,spontaneous abortion and perinatal mortality in the observation group were 63.33%,16.67%,14.44%,2.22%.The postpartum outcome in the control group was significantly better than that in the observation group,which was statistically significant（P〈0.05）.The total obstetric complication rate in the observation group was significantly higher than that in the control group,which was statistically significant（χ~2=11.45,P〈0.05）.There were significant differences in birth weight,body length and 1 min Apgar score between the two groups.The birth in the control group was significantly better than that in the observation group,which was statistically significant（P〈0.05）.Conclusion Maternal hypothyroidism during pregnancy and the huge impact on infant health should be given attention,and prenatal screening for hypothyroidism should be promoted.
出处
《中国现代医生》
2017年第1期18-21,共4页
China Modern Doctor
