摘要
便秘型肠易激综合征(C-IBS)是一种临床最常见的功能性肠道疾病,临床主要表现为腹部不适、腹痛、大便排出困难或排便间隔时间延长,伴有抑郁、焦虑等精神症状,未发现胃肠道结构改变以及生化学检查的异常,经完善相关检查可排除相关器质性疾病。C-IBS当归属于中国医学"腹痛""便秘"的范畴。C-IBS发病的病理生理机制,目前尚未完全阐明,目前认为其发病与胃肠运动功能紊乱、微生物群的改变、内脏高敏感性、基因遗传因素、炎症及免疫成分的改变、Cajal间质细胞和脑-肠轴的神经内分泌功能紊乱等有关。研究其发病机制对于提高患者的生活质量及合理利用医疗资源至关重要。现从中西医两方面对其发病机制的最新进展作一综述。
Constipation-predominant irritable bowel syndrome（C-IBS）is one of the most common clinical functional bowel disease,which mainly expresses clinical abdominal discomfort,abdominal pain,defecate eduction difficulty or defecation time interval extension,associating with depression,anxiety and mental symptoms,finding no gastrointestinal structure change and abnormal biopsy,by perfecting the relevant examination related physical problem could be eliminated. C-IBS angelica belonging to Chinese medicine＂pain＂＂constipation＂category. The pathophysiology of C-IBS pathogenesis,at present has not been fully elucidated,now thinking its pathogenesis and gastrointestinal motor function disorder,changes in the microbiota,visceral high sensitivity,genetic factors,the change of inflammation and immune components,Cajal interstitial cells and brain-gut axis of neuroendocrine dysfunction and so on. Studying the pathogenesis for improving the patients＇ quality of life and rational utilization of medical resources is of crucial importance. Now this article summarizes from the latest progress of the pathogenesis of both Chinese and Western medicine.
出处
《辽宁中医药大学学报》
CAS
2017年第3期94-97,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
江苏省中医药局科技项目(ZD201507)
江苏省科技项目(BK20151046)
关键词
便秘型肠易激综合征
病因病机
机制
脑-肠轴
研究进展
constipation-predominant irritable bowel syndrome
etiology and pathogenesis
pathogenesis
brain-gut axis
recent advance
