摘要
目的:观察苗药铁筷子醇提物对佐剂性关节炎模型(AA)大鼠的作用,并探讨其作用机制。方法:建立大鼠佐剂性关节炎模型,观察AA大鼠的一般情况、足肿胀情况,计算免疫器官系数;采用酶联免疫法测定大鼠血清中肿瘤坏死因子-α(TNF-α)、血小板活化因子(PAF)的含量。结果:与模型组比较,铁筷子醇提物能够改善AA大鼠的一般情况,抑制大鼠足肿胀,对免疫器官没有明显影响;可明显降低AA大鼠血清中TNF-α、PAF的含量。结论:铁筷子醇提物对佐剂性关节炎大鼠具有一定的治疗作用,其作用机制可能与降低TNF-α、PAF的水平有关。
Objective：To study the effects of alcohol extract from Chimonanthus praecox on adjuvant arthritis rats and their mechanism. Methods：To establish the adjuvant arthritis model in rats,and then to observe the paw swelling,calculate coefficient of immune organs and detect the levels of TNF-α,PAF in the serum of AA rats by enzyme linked immunosorbent assay（ELISA）. Results：The alcohol extract from Chimonanthus praecox could improve the general situation,effectively inhibit the articular swelling of AA rats and the levels of TNF-α and PAF in the serum were decreased significantly,but it had no significant effects on the immune organs,compared with model group. Conclusion：The alcohol extract from Chimonanthus praecox had certain therapeutic effects on adjuvant arthritis rats,and its mechanism might be related to the reduction of the levels of TNF-α,PAF.
出处
《辽宁中医药大学学报》
CAS
2017年第3期19-21,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
贵州省科技厅联合基金项目(黔科合中药字[2012]LKZ7030)
贵阳市科技计划项目(筑科合同[2011204]22号)
关键词
铁筷子
醇提物
佐剂性关节炎
肿瘤坏死因子-Α
血小板活化因子
Chimonanthus praecox
alcohol extract
adjuvant arthritis
tumor necrosis factor α
platelet activating factor
