摘要
目的探讨老年肺癌放化疗前后肺部感染的病原菌感染情况以及药敏分析结果。方法收集进行放化疗的老年肺癌患者97例作为研究对象,对其病原菌培养结果及药敏分析结果进行回顾性分析。结果 97例患者放化疗前共分离出病原菌85株,其中革兰阴性菌67.06%,革兰阳性菌8.24%,真菌24.71%;放化疗后共分离出病原菌110株,其中革兰阴性菌55.45%,革兰阳性菌6.36%,真菌38.18%。治疗后真菌所占比例明显高于放化疗前,差异有统计学意义(P<0.05)。放化疗后铜绿假单胞菌对亚胺培南耐药率显著升高,较放化疗前差异有统计学意义(P<0.05),而对其他药物耐药率无统计学差异(P>0.05)。放化疗前后肺炎克雷伯菌对各药物耐药率均无统计学差异(P>0.05)。放化疗前白色念珠菌对几种药物耐药率均较低,放化疗后,氟康唑、氟胞嘧啶耐药率较放化疗前略升高,但差异无统计学意义(P>0.05)。结论放化疗后老年肺癌患者真菌感染率增高,对于大部分患者耐药率影响不显著。
Objective To explore the pathogen infection and drug sensitivity of of lung infections in elderly patients with lung cancer after chemoradiotherapy .Methods 97 elderly patients with lung cancer underwent chemoradiotherapy were selected . Then the pathogen culture and drug sensitivity results were retrospectively analyzed .Results 85 pathogens were found out before chemoradiotherapy,including 67.06%gram-negative bacteria,8.24%gram-positive bacteria and 24.71%fungus.110 pathogens were found out after chemoradiotherapy ,including 55.45% gram-negative bacteria ,6.36% gram-positive bacteria and 38.18%fungus.The amounts of fungus after therapy were obviously higher than before with statistically significance （P〈0.05）.The re-sistance rate of pseudomonas aeruginosa to imipenem increased after therapy （P〈0.05）,but had no statistically significance （P〉0.05）.Canidida albicans had low resistance rate to the drugs ,but to fluconazole and flucytosine after therapy were increased without significant difference （P〉0.05）.Conclusion The infection rate of fungus increased after chemoradiotherapy ,but there have no significant effect on drug resistance rate .
出处
《实用癌症杂志》
2017年第3期466-468,共3页
The Practical Journal of Cancer
关键词
肺癌
放化疗
肺部感染
病原菌培养
药敏
Lung cancer
Chemoradiotherapy
Lung infection
Pathogen culture
Drug resistance
