摘要
目的探讨妊娠期肝内胆汁淤积症(ICP)对母婴结局的影响。方法以2008年1月~2015年12月在我院接受救治的65例ICP患者为研究组,根据患者血清总胆汁酸水平将其分为轻度组(43例)与重度组(22例)。选择同期前来我院体检的健康产妇71例为对照组,观察两组患者母婴结局的差异。结果研究组早产、羊水粪染、剖宫产及产后出血的发生率均明显高于对照组,差异有统计学意义(P<0.05);研究组胎膜早破发生率与对照组比较,差异无统计学意义(P>0.05);研究组低体重儿、胎儿窘迫及新生儿窒息的发生率与对照组比较,差异有统计学意义(P<0.05)。重度组早产、羊水粪染、低体重儿、胎儿窘迫、新生儿窒息的发生率均高于轻度组(P<0.05);两组胎膜早破、剖宫产、产后出血的发生率比较,差异无统计学意义(P>0.05)。结论妊娠期ICP是导致不良母婴结局的一项重要原因,护理人员应加强对产妇的产前检查以及围生期的胎儿监护护理,对妊娠期肝内胆汁淤积做到早检测、早预防、早治疗。
Objective To explore the effect of intrahepatic cholestasis of pregnancy（ICP） on maternal and neonatal outcomes.Methods 65 patients with ICP from January 2008 to December 2015 treated in our hospital were selected as study group,and they were divided into mild group（43 cases） and severe group（22 cases） according to the level of serum total bile acid;71 healthy parturient from our hospital at the same period were selected as control group.The difference of maternal and infant outcome between two groups were observed.Results Incidence of premature,meconium stained amniotic fluid,cesarean section and postpartum hemorrhage in study group was obvious higher than that in the control group respectively,the difference was statistically significant（P〈0.05）;the incidence of premature rupture of membranes in the two groups had no significant difference（P〈0.05）;the incidence of low birth weight infants,fetal distress and neonatal asphyxia of the study group was compared with the control group,and the difference was statistically significant（P〈0.05）.Incidence of premature,meconium stained amniotic fluid,low birth weight infants,fetal distress and neonatal asphyxia in severe group was higher than that in mild group respectively（P〉0.05）,the incidence of premature rupture of membranes,cesarean section,and postpartum hemorrhage had no significant difference between two groups（P〈0.05）.Conclusion Intrahepatic cholestasis of pregnancy is an important cause of adverse maternal and neonatal outcomes,nursing staff should strengthen prenatal care for maternal and perinatal fetal care.Early detection,prevention and treatment should be done for intrahepatic cholestasis of pregnancy.
作者
潘方利
梁权芳
周银燕
PAN Fang-li LIANG Quart-fang ZHOU Yin-yan(Deqing County Maternity and child Care Centers in Guangdong Province,Deqing 526600,Chin)
出处
《中国当代医药》
2017年第5期61-63,共3页
China Modern Medicine
关键词
妊娠期肝内胆汁淤积症
总胆汁酸
围生儿
母婴结局
Intrahepatic cholestasis of pregnancy
Total bile acid
Perinatal infant
Maternal and neonatal outcomes
