摘要
目的测定0~3岁反复上呼吸道感染(r URTIs)患儿血清细胞因子IL-6、IL-10、TNF-α水平变化并探讨其意义。方法选取2013年5月至2014年4月治疗的0~3岁r URTIs患儿90例,其中0~1岁30例,1~2岁30例,2~3岁30例,将其列为观察组,另选取0~3岁健康儿童90例为对照组,其中0~1岁30例,1~2岁30例,2~3岁30例,检测血清细胞因子IL-6、IL-10、TNF-α水平,比较其差异。结果 0~3岁组r URTIs患儿血清IL-6水平明显高于对照组(P<0.01);0~1岁、2~3岁组r URTIs患儿血清IL-10水平与对照组差异无统计学意义(P>0.05),1~2岁、0~3岁组r URTIs患儿血清IL-10水平明显低于对照组(P<0.01,P<0.05);0~1岁、1~2岁、2~3岁、0~3岁反复上感组患儿血清TNF-α水平明显高于对照组(P<0.05或<0.01)。结论 0~3岁r URTIs患儿血清细胞因子IL-6、IL-10、TNF-α有明显变化,提示细胞因子参与了r URTIs的发病,幼儿细胞免疫功能下降对r URTIs的发生、发展具有重要意义。
Objective To observe the changes of serum levels of interleukin-6 （ IL-6 ） , interleukin-10 （ IL-10 ） and tumor necrosis factor-α（ TNF-α） in children patients with recurrent upper respiratory tract infection （ rURTIs） in 0~3 years age group,and to explore its significance .Methods Ninety children patients with rURTIs in 0~3 years age group who were treated in our hospital from May 2013 to April 2014 were enrolled as observation group in which 30 cases in 0~1 year group, 30 cases in 1~2 years group and 30 cases in 2~3 years group,moreover, the other 90 healthy children were served as control group in which 30 cases in 0~1 year group, 30 cases in 1~2 years group and 30 cases in 2~3 years group.The serum levels of IL-6,IL-10,TNF-αwere detected and compared among the groups .Results The serum levels of IL-6 in observation group were significantly higher than those in control group （ P〈0.01）,however,there were no significant differences in the serum levels of IL-10 between 0~1 year group and 2~3 years group （ P〉0.05）.The serum levels of IL-10 in 1~2 years group and 0~3 years group of observation group were significantly lower than those in control group （ P〈0.01, P〈0.05）. Moreover the serum levels of TNF-αin 0 ~1 year group, 1 ~2 years group, 2 ~3 years group of observation group were significantly higher than those in control group （ P〈0.05 or P〈0.01）.Conclusion The serum levels of IL-6,IL-10 and TNF-αin children patients with rURTIs in 0 ~3 years age group are changed obviously , which suggests that cytokines are involved in the pathogenesis of rURTIs , and the decrease of cellular immune function of children plays an important role in the pathogenesis and development of rURTIs .
出处
《河北医药》
CAS
2017年第1期14-16,共3页
Hebei Medical Journal
基金
珠海市科技局项目(编号:2012D0401990023)
