摘要
目的观察ACEI类药物对腔隙性脑梗死患者脑血管反应性(cerebral vascular reactivity,CVR)的影响及作用机制。方法 31例腔隙性脑梗死患者作为研究对象,37例年龄、性别匹配的单纯高血压病患者作为对照。所有被研究者以贝那普利干预3个月,并于干预治疗前、疗程结束后通过TCD以屏气试验方法检测血管反应性(P<0.05)。通过Pearson积差分析BHI改善与血压下降的相关性。结果 2组患者BHI值改善与血压降低程度无相关性(P>0.05),说明ACEI类药物对脑血液动力学的影响独立于其降压作用之外,ACEI类药物具有神经保护作用。结论 ACEI类药物对于腔隙性脑梗死患者的脑血管调节能力具有改善作用,且这种作用与其降压作用无关。
Objective To observe the effects of angiotensin converting enzyme inhibitors on cerebral vascular reactivity （ CVR ） in patients with hypertension complicated by lacunar cerebral infarction , and to explore its action mechanism.Methods Thirty-one patients with lacunar cerebral infarction were enrolled as observation group in the study , moreover , the other 31 patients with hypertension （ the same age and sex as those in observation group ） were served as control group.All the subjects were treated by benazepril for three months ,and the CVR of patients was detected by routine TCD and breath-holding test before and after treatment .Moreover the correlation between breath-holding index （ BHI） improvement and blood presure decrease was evaluated by means of Pearson product-moment analysis .Results There was no correlation between BHI improvement and blood presure decrease in both groups （ P 〈0.05）,which suggested that the effects of ACEI drugs on brain haemodynamics were independent of antihypertensive effects , moreover, ACEI drugs had neuroprotection effects.Conclusion ACEI drugs can improve cerebral vascular regulation ability in patients with lacunar cerebral infarction , moreover , the action is not related with its antihypertensive effects .
出处
《河北医药》
CAS
2017年第3期375-377,共3页
Hebei Medical Journal
基金
河北省医学科学研究重点课题(编号:20110411)
关键词
脑血管反应性
血管紧张素抑制剂
经颅多普勒超声
腔隙性脑梗死
cerebral vascular reactivity
angiotensin converting enzyme inhibitor
transcranial Doppler sonography
lacunar cerebral infarction
