摘要
目的:探讨感染对儿童初发系统性红斑狼疮病情活动度的影响。方法:通过回顾性研究收集儿童系统性红斑狼疮病例86例,通过整理病史、体格检查及统计实验室检查结果等方法统计相关临床及实验室资料。根据以上资料分为感染组和对照组,通过比较分析两组资料探讨感染对初发儿童SLE病情活动度的影响情况。结果:1)SLE患儿感染发生率为52.3%,感染部位以呼吸道多见,占40%,其次为消化道和泌尿道,病原体以细菌多见,占62.2%,其次为支原体、病毒;2)感染组的ds-DNA、CD3^+CD8^+(Ts)细胞、CD3^-CD19^+(B)细胞、SLEDAI评分均明显高于对照组(P<0.05);感染组补体数量明显低于对照组(P<0.05),感染组抗感染治疗后,ds-DNA、CD3^+CD8^+(Ts)细胞、SLEDAI评分较治疗前明显下降(P<0.05),而补体数量及CD3^-CD16^+CD56^+(%)细胞较治疗前明显上升(P<0.05)。结论:儿童SLE患者较易合并感染,发病初期及合并感染会加重儿童系统性红斑狼疮的病情,及时有效控制感染有助于改善儿童SLE患者的病情。
Objective： To investigate the effect of infection on the disease activity of children newly diagnosed with systemic lupus erythematosus（SLE）. Methods： 86 cases of children with SLE were divided into the infected group and the control group and retrospectively studied, the medical history, physical examination and laboratory test results were compared between two groups. Results：1） SLE infection rate was 52.3% in children, respiratory tract infection was more common, accounting for 40%, followed by the digestive tract and urinary tract, bacterial pathogens common, accounting for 62.2%, followed by mycoplasma, viruses; 2） The ds-DNA, CD3^＋CD8^＋（Ts） cells, CD3--CD19^＋（B） cells, SLEDAI scores of infected group were significantly higher（P〈0.05）; the number of complement in infected group was significantly lower than the control group（P〈0.05）, the ds-DNA, CD3^＋CD8^＋（Ts） cells, before SLEDAI scores of infected group were decreased significantly after anti-infection treatment than before treatment（P〈0.05）, while the number of complements and CD3^-CD16^＋CD56^＋（%） cells were significantly increased（P〈0.05）. Conclusion： Children with SLE were easier to infection, and early onset of infection could aggregate the condition of SLE, timely and effective infection control could help improve the condition of SLE.
出处
《现代生物医学进展》
CAS
2017年第2期260-264,共5页
Progress in Modern Biomedicine
基金
基金项目:上海交通大学医学院附属仁济医院南院系统性自身免疫病多学科转化医学平台(2014MDT01)
关键词
系统性红斑狼疮
感染
儿童
病情活动
Systemic Lupus Erythematosus（SLE）
Infection
Children
Disease activity
