摘要
目的对比酚妥拉明与硝普钠治疗冠心病心力衰竭的临床疗效。方法 80例冠心病心力衰竭患者,按照治疗方法不同分为A组(37例)和B组(43例)。A组患者给予硝普钠治疗,B组患者给予酚妥拉明治疗,比较两组疗效。结果 A组患者总缓解36例(97.3%);B组患者总缓解35例(81.4%),A组总缓解率明显高于B组,差异具有统计学意义(P<0.05)。治疗前两组患者左室舒张末内径(LVEDD)、左室射血分数(LVEF)、左室收缩末内径(LVESD)比较差异无统计学意义(P>0.05);两组患者治疗后LVEDD、LVEF、LVESD较治疗前改善显著(P<0.05),治疗后A组患者LVEDD为(56.14±3.35)mm、LVEF为(47.05±6.70)%、LVESD为(36.70±4.25)mm,改善状况明显优于B组的(59.87±7.76)mm、(37.22±5.55)%、(40.35±4.32)mm,差异具有统计学意义(P<0.05)。结论硝普钠治疗心力衰竭无论从症状改善还是心功能相关指标改善方面均优于酚妥拉明,安全性高,值得在临床治疗中广泛推广。
Objective To compare clinical effect between phentolamine and sodium nitroprusside in the treatment of coronary heart disease heart failure. Methods A total of 80 patients with coronary heart disease heart failure were divided by different treatment measures into group A（37 cases） and group B（43 cases）. Group A received sodium nitroprusside for treatment, and group B received phentolamine for treatment. Curative effects were compared between the two groups. Results There were 36 total remission cases in group A（97.3%） and 35 total remission cases in group B（81.4%）. Group A had obviously higher total remission rate than group B, and the difference had statistical significance（P〈0.05）. Before treatment, there was no statistically significant difference of left ventricular end-diastolic dimension（LVEDD）, left ventricular ejection fraction（LVEF） and left ventricular end-systolic dimension（LVESD） between the two groups（P〉0.05）. Both groups had obviously improved LVEDD, LVEF and LVESD after treatment（P〈0.05）. After treatment, group A had LVEDD as（56.14±3.35） mm, LVEF as（47.05±6.70）% and LVESD as（36.70±4.25） mm, which showed obviously better improvements than（59.87±7.76） mm,（37.22±5.55）% and（40.35±4.32） mm in group B, and their difference had statistical significance（P〈0.05）. Conclusion Sodium nitroprusside acts better in improving symptoms and cardiac function indexes than phentolamine in treating heart failure, along with high safety. This method is worth wide promotion in clinical treatment.
作者
刘振金
LIU Zhen-jin(Department One of Cardiology, Inner Mongolia Chifeng City Second Hospital, Chifeng 024000, Chin)
出处
《中国实用医药》
2017年第3期99-101,共3页
China Practical Medicine
关键词
硝普钠
酚妥拉明
冠心病
心力衰竭
Sodium nitroprusside
Phentolamine
Coronary heart disease
Heart failure
