摘要
目的 :探讨维生素 E(Vit E)对急性胰腺炎 (AP)时过氧化脂质、花生四烯酸代谢产物产生的影响及其对 AP的治疗效果及机理。方法 :采用“十二指肠闭袢法”复制 AP大鼠模型 ,分别观察实验性 AP大鼠和临床 AP患者血浆丙二醛 (MDA)、血栓素 (TXB2 )的变化 ,以及 Vit E对上述指标的影响。结果 :Vit E可使实验性 AP大鼠和临床 AP患者血浆 MDA、TXB2 明显下降 ,并可明显改善 AP大鼠胰腺的病理改变 ,控制临床 AP患者的症状和体征 ,有效率综合评价达 91.4 %。结论 :Vit E可通过直接抑制脂质过氧化反应 ,间接阻止花生四烯酸代谢系统紊乱而达到治疗 AP的效果 ,是临床治疗
Objective: To evaluate the effects of vitamin E on the production of lipid peroxide and eicosanoid meta of acute pancreatitis (AP), and the therapeutic effect and mechanism of Vitamin E. Methods: The model of rat AP by the use of a closed duodenal loop technique was constructed. The plasma content of malondialdehyde (MDA), and the plasma levels of TXB 2 were measured in AP rats and patients with AP respectively. Effects of Vitamin E treatment on the alteration of the plasma leves of MDA and TXB 2 were also examined. The therapeutic effect of Vitamin E was assessed. Results: Vitamin E could significally decrease the plasma levels of MDA and TXB 2 in AP rats and the patients with AP, also mitigate the pancreatic pathological show in rats AP, alleviate the symptoms and signs of the patients with AP. The effective rate of treating AP with Vitamin E reached 90 percent. Conclusions: Vitamin E, which can take good therapeutic effects on AP by limiting lipid peroxidation and eicosanoid imbalance, is an effective and cheap drug for AP. [
出处
《南通医学院学报》
2002年第3期251-253,共3页
ACTA Academiae Medicinae Nantong
