摘要
目的研究重组人脑利钠肽(rhBNP)对行经皮冠状动脉介入术(PCI)术后并发心力衰竭的急性心肌梗死(AMI)患者心脏功能、N末端B型钠尿肽原(NT-proBNP)水平的影响。方法选择2014年1月至2016年3月在该院行PCI术后并发心力衰竭的AMI患者150例,采用随机数字表法分为对照组和试验组,每组各75例,对照组给予常规治疗,试验组则加用rhBNP。比较两组患者的疗效、心功能指标、心血管不良事件和NT-proBNP水平等。结果试验组患者的总有效率为88.00%,对照组患者的总有效率为72.00%,差异有统计学意义(P<0.05)。治疗前两组患者的NT-proBNP、心肌肌钙蛋白I(cTnI)、血浆脑利钠肽(BNP)、血清肌酸激酶同工酶(CK-MB)水平相近,差异无统计学意义(P>0.05),治疗后两组患者的以上指标均明显下降,试验组以上指标水平更低,差异有统计学意义(P<0.05)。治疗前两组患者的左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)和左心室射血分数(LVEF)等心功能指标相比,差异无统计学意义(P>0.05),治疗后试验组心功能指标更优,差异有统计学意义(P<0.05)。试验组患者心血管不良事件的发生率为5.33%,明显低于对照组,差异有统计学意义(P<0.05)。结论 rhBNP应用可以提高行PCI术后并发心力衰竭AMI患者的疗效,改善心脏功能,降低NT-proBNP水平和心血管不良事件的发生率。
Objective To study the effect of recambinant human brain natriuretic peptide（rhBNP） on cardiac function,NT-proB- NP levels in the patients with acute myocardial infarction（AMI） complicated with heart failure after PCI. Methods One hundred and fifty patients with AMI complicated with heart failure after PCI in our hospital from January 2014 to March 2016 were selected and divided into the control group and experimental group by the random number table method, 75 eases in each group. The control group was given the conventional treatment, while the experimental group was added with rhBNP. The curative effect, cardiac function indexes,adverse cardiovascular events and NT-proBNP levels were compared between the two groups. Results The total effective rate of the experimental group was 88.00% and which of the control group was 72.00% ,the difference had statistical significance（P〈0.05）. Before treatment, the levels of NT proBNP, cTnI, BNP, CK-MB levels in the two groups were similar, the difference had no statistical significance（P〉0.05）, the levels of above indicators after treatment in the two groups were significantly decreased, the levels of above indicators in the experimental group were lower, the difference was statistically significant （P〈0.05）. Before treatment,the heart function indexes of LVEDV, LVESV and left ventricular ejection {raction（LVEF） in the two groups were similar,the difference was not statistically significant（P〉0.05） ,but the cardiac function indicators in the experimental group were more excellent, the difference had statistical significance（P〈0.05）. The incidence rate of adverse cardiovascular events in the experimental group was 5.33 %,which was significantly lower than that in the control group, the difference had statistical significance（P〈0.05）. Conclusion The RhBNP application can improve the curative efficacy in the AMI patients complicated with heart failure after PCI surgery,improves the cardiac function, reduces the NT-proBNP level and occurrence rate of cardiovascular adverse events.
出处
《检验医学与临床》
CAS
2017年第5期650-652,共3页
Laboratory Medicine and Clinic
关键词
急性心肌梗死
心力衰竭
重组人脑利钠肽
acute myocardial infarction
heart failure
recambinant human brain natriuretic peptide
