摘要
目的探讨腹腔镜下子宫肌瘤剔除术对患者卵巢功能、血清疼痛指标及氧化损伤指标的影响。方法回顾性分析该院60例子宫肌瘤患者临床资料,以腹腔镜下子宫肌瘤剔除术治疗者为观察组(30例),以开腹子宫肌瘤剔除术治疗者为对照组(30例)。分别于术前,术后1、3、6个月检测患者血清卵巢功能指标[雌二醇(E2)、黄体生成素(FSH)、促黄体生成素(LH)];于术前,术后1、3、5d检测血清疼痛指标[心肌细胞P物质(SP)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)]及氧化损伤指标[肌红蛋白(MYO)、血清缺血修饰清蛋白(IMA)、八廓环磷酰胺(TAC)]。结果观察组患者术后1、3、6个月血清E2水平明显高于对照组,而LH、FSH水平明显低于对照组,差异有统计意义(P<0.05);观察组患者术后1、3、5d血清IL-6、SP及PGE2水平明显低于对照组,差异有统计意义(P<0.05)。观察组患者术后1、3、5d血清TAC水平明显高于对照组,而MYO、IMA水平明显低于对照组,差异有统计意义(P<0.05)。结论腹腔镜下子宫肌瘤剔除术治疗可减轻患者疼痛及对卵巢功能的影响,适宜临床应用推广。
Objective To explore the influence of laparoscopic myomectomy on the ovarian function,serum pain indexes and oxidative damage indexes of the patients.Methods The clinical data of 60 patients with uterine myoma in our hospital were retrospectively analyzed,including the observation group（30cases）treated by laparoscopic myomectomy and the control group（30cases）treated by laparotomy myomectomy.Respectively,the serum ovarian function indexes of estradiol（E2）,follicle-stimulating hormone（FSH）and luteinizing hormone（LH）were detected before operation and at postoperative 1,3,6months.Serum pain indicators of cardiomyocyte substance P（SP）,interleukin-6（IL-6）and prostaglandin E2（PGE2）,and oxidative damage markers such as myoglobin（MYO）,serum missing serum albumin modified（IMA）and TAC were detected before operation and at postoperative 1,3,5d.Results Serum E2 levels at postoperative 1,3,6months in the observation group were significantly higher than those in the control group,while the LH and FSH levels were significantly lower than those in the control group,the differences were statistically significant（P〈0.05）;serum IL-6,SP,and PGE2 levels at postoperative 1,3,5din the observation group were significantly lower than those in the control group,the difference was statistically significant（P〈0.05）.Serum TAC levels at postoperative 1,3,5din the observation group were significantly higher than those in the control group,while the MYO and IMA levels were significantly lower than those in the control group,the difference was statistically significant（P〈0.05）.Conclusion Laparoscopic myomectomy therapy can reduce the patient′s pain and influence on the ovarian function,which is suitable for clinical application and promotion.
出处
《检验医学与临床》
CAS
2017年第5期627-629,共3页
Laboratory Medicine and Clinic
