摘要
目的探讨血浆同型半胱氨酸(Hcy)水平对女性高血压患者冠状动脉病变及左心室功能的影响。方法 354例女性高血压患者分为H型高血压组(血浆Hcy≥10μmol/L,240例)和非H型高血压组(血浆Hcy<10μmol/L,114例),比较两组患者冠状动脉病变特点及左心室功能。结果H型高血压组患者冠状动脉Gensini总分、左心室重量指数、左心室室壁张力高于非H型高血压组,而左心室射血分数低于非H型高血压组(P<0.05)。两组患者左心室等容舒张时间、E峰值和E/A比较均有统计学差异(P<0.05),而A峰值、e’峰值、a’峰值、e’/a’、E/e’比较差异无统计学意义(P>0.05)。结论女性H型高血压患者和非H型高血压患者在冠状动脉病变、左心室收缩功能及部分舒张功能上存在差异;血浆Hcy水平增高是女性高血压患者冠状动脉粥样硬化及左心室功能减退的危险因素。
Objective To explore the effects of plasma homocysteine（Hcy）on coronary artery lesions and left ventricular functions in female patients with essential hypertension（EH）.Methods A total of 354 female EH patients was divided into two groups of A（plasma Hcy≥10μmol/L,240cases）and B（plasma Hcy10μmol/L,114cases）.The characteristics of coronary artery lesions and left ventricular functions were compared between two group.Results The coronary artery Gensini score,left ventricular mass index and left ventricular chamber wall tension were higher and left ventricular ejection fraction was lower in group A than those in group B（P〈0.05）.The left ventricular isovolumetric relaxation time,peak E and E/A were significantly different between two groups（P〈0.05）.There were no significant differences in peak A,peak e＇,peak a＇,e＇/a＇,E/e＇between two groups（P〉0.05）.Conclusion There are significant differences in coronary artery lesions,left ventricular systolic functions and part of left ventricular diastolic function between female patients with H type EH and non-H type EH.Elevated plasma expression of Hcy is a risk factor for coronary artery atherosclerosis and reduction of left ventricular systolic dysfunction in female patients with EH.
出处
《江苏医药》
CAS
2017年第4期261-264,共4页
Jiangsu Medical Journal
关键词
同型半胱氨酸
高血压病
冠状动脉病变
左心室功能
Homocysteine
Essential hypertension
Coronary artery lesions
Left ventricular function
