摘要
胆汁酸具有多种重要的生理功能,不仅与脂类物质的消化吸收密切相关,还可作为激素样信号分子在胆汁酸、脂类与糖类物质代谢及能量代谢等方面发挥重要作用。近年研究发现,胆汁酸及其核受体法尼酯X受体(FXR)在细胞增生、分化、凋亡和肝再生的调控中也发挥重要作用。本文综述了胆汁酸及其核受体FXR在细胞增生、分化、凋亡和肝再生的作用及机制,以及在寄生虫-细粒棘球绦虫成虫发育分化中作用的研究进展。
The bile acids have many important physiological functions and are shown to play key roles in the digestion and absorption of dietary lipids and fat soluble vitamins as well as in regulating the bile acid homeostasis, the lipids, the glucose and the energy metabolism.Recent evidences suggest that the bile acids and their nuclear receptor FXR play an important role in the cell proliferation, the differentiation, the apoptosis and the normal liver regeneration. This review elucidates the potential role of the bile acid-FXR signaling pathway in the cell proliferation, the differentiation and the liver regeneration, as well as highlights possible mechanisms involved. With the development of the bile acid- FXR signaling pathway in the cell proliferation, the differentiation and the liver regeneration, the related fundamental scientific research will be turned into practical applications in the clinical and preventive medicine.
出处
《科技导报》
CAS
CSCD
北大核心
2017年第4期79-83,共5页
Science & Technology Review
基金
国家自然科学基金项目(31260272)
2014新疆医科大学科研创新基金项目(XYDCX201423)
关键词
胆汁酸
法尼酯X受体
细胞增生
肝再生
细胞分化
bile acids
farnesoid X receptor
cell proliferation
liver regeneration
cell differentiation
