摘要
目的:研究扩张型心肌病(DCM)不同心功能状态时甲状腺激素水平的变化。方法:选取DCM患者106例,NYHAⅡ级32例(Ⅱ级组),NYHAⅢ级48例(Ⅲ级组),NYHAⅣ级26例(Ⅳ级组)。入院后完善生化检查和心脏超声。再根据患者血清游离三碘甲状腺原氨酸(FT3)水平四分位数进行分组,比较不同FT3组左室射血分数(LVEF)、高敏C反应蛋白(hsCRP)、氨基末端B型脑钠肽前体(NT-proBNP)的差别。结果:经单因素方差分析,NYHAⅡ级组、Ⅲ级组、Ⅳ级组之间NT-proBNP、hsCRP的差异有统计学意义(P<0.01);FT3和总三碘甲状腺原氨酸(TT3)之间差异亦有统计学意义(P<0.01);而促甲状腺激素(TSH)、游离甲状腺素(FT4)、总甲状腺素(TT4)无统计学意义(P>0.05)。在以FT3四分位数进行分组中,FT3越低,LVEF就越低,而hsCRP和NT-proBNP越高。结论:DCM的FT3越低,则LVEF越低,同时hsCRP、NT-proBNP越高,预测患者的临床风险的增加。
Objective：To investigate the relationship between thyroid hormone levels and heart function in patients with dilated cardiomyopathy.Method：A total of 106 patients with dilated cardiomyopathy was enrolled in this study,including 32 patients in NYHA Ⅱ group,48 patients in NYHAⅢ group,26 patients in NYHA Ⅳgroup.Laboratory and echocardiographic indicators were collected.Based on serum FT3 level,quartile subgroup were adopted.We analysis the left ventricular ejection fraction（LVEF）,high sensitivity C-reactive protein（hsCRP）,N-Terminal pro-brain natriuretic peptide precursor（NT-proBNP）in different FT3 subgroups.Result：Among the NYHAⅡ,Ⅲ andⅣ groups,NT-proBNP and hsCRP had significant differences（P〈0.01）.FT3 and TT3had significant differences（P〈0.01）,while TSH,FT4,and TT4didn＇t have any differences（P〉0.05）.In the lower FT3 group,we would found the lower LVEF is lower,and the higher hsCRP and NT-proBNP is higher.Conclusion：Low FT3 usually associates with low LVEF or high hsCRP and NT-proBNP,which predicts high clinical risks in patients with dilated cardiomyopathy.
作者
梁琦
殷艳蓉
雷新军
韩克
黄欣
任洁
李红兵
袁祖贻
LIANG Qi YIN Yanrong LEI Xinjun HAN Ke HUANG Xin REN Jie LI Hongbing YUAN Zuyi(Department of Cardiology, the First Affiliate Hospital of Xi＇an Jiaotong University, Xi＇an, 710061 ,China)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2017年第2期123-128,共6页
Journal of Clinical Cardiology
基金
西安市科技计划项目(No:SF1416-2)
关键词
扩张型心肌病
氨基末端B型脑钠肽前体
游离三碘甲状腺原氨酸
高敏C反应蛋白
左室射血分数
dilated cardiomyopathy
N Terminal pro-brain natriuretic peptide precursor
free triiodothyronin
high sensitivity C-reactive protein
left ventricular ejection fraction
