摘要
放射性心肌纤维化是放射性心脏损伤(radiation-induced heart disease,RIHD)的重要病理过程,可导致心脏功能下降、心肌重塑等,影响患者生存质量。既往多位学者在细胞、分子、基因等层面对此进行了研究,一般认为是纤维母细胞异常分化、微血管内皮损伤、炎症、氧化应激反应、转化生长因子-β1(TGF-β1)信号转导、基因表达改变等多种因子及信号通路相互作用的结果,但分子生物学机制错综复杂,仍未完全明确,目前尚无有效的临床干预措施。本文旨在探讨RIHD心肌纤维化的发生机制及临床干预措施,并对其新进展、面临的挑战以及未来的发展方向做一概述。
Summary Radiation induced myocardial fibrosis is the important pathological characteristic of radiation-induced heart disease（RIHD）. It can lead to decreased cardiac function and cardiac remodeling, affecting the life quality of patients severly. Some researches had been carried out on how irradiation acts on a cellular, molecular, and genetic levels, etc. It is thought to be the result of interaction of signaling pathways, including abnormal fibro blast differentiation, microvascular endothelial injury, inflammation, oxidative stress, TGF-betal signal transduc- tion, gene expression changes, and so on. But its molecular mechanisms are complex and not to be clarified, and there are not effective interventions to reverse radiation-induced myocardial fibrosis. This manuscript aims to review the mechanism and clinical interventions of radiation-induced myocardial fibrosis, and overview new progress, challenges and research prospective direction of the field.
作者
刘丽娜
武亚晶
王军
LIU Lina WU Yajing WANG Jun(Department of Radiotherapy Oncology, the 4th Hospital of Hebei Medical University, Shijiazhuang, 050011, China)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2017年第2期110-114,共5页
Journal of Clinical Cardiology
关键词
放射性心脏损伤
放射性心肌纤维化
发病机制
radiation-induced heart disease
radiation induced myocardial fibrosis
Mechanism
