摘要
目的观察双抗血小板联合阿托伐他汀治疗对高龄冠心病经皮冠状动脉介入治疗（PCI）术患者颈动脉硬化斑块及心肌功能的影响。方法将2014年1月至2016年2月本院收治的66例高龄冠心病PCI术患者随机数字表法均分为研究组和对照组，两组均实施双抗血小板治疗，研究组另给予阿托伐他汀治疗，观察两组治疗前后颈动脉硬化斑块[颈动脉内中膜厚度（IMT）、斑块面积（PA）]、心肌功能指标[肌酸激酶同工酶（CKMB）、肌钙蛋白I（cTNI）1及治疗期间不良心血管事件发生率。结果两组治疗结束后IMT、PA均较治疗前显著减小，且治疗结束后研究组IMT、PA较对照组显著减小，差异均有统计学意义（均P〈0．05）；治疗结束后仅对照组CKMB、cTNI较治疗前显著升高，且治疗结束后研究组CKMB、cTNI显著低于对照组（P〈0．05）；治疗期间研究组不良心血管事件总发生率较对照组显著低（P〈0．05）。结论双抗血小板联合阿托伐他汀治疗可显著减小高龄冠心病PCI术患者的颈动脉硬化斑块，且有效减轻对心肌功能损害程度。
Objective To observe the effect of dual antiplatelet therapy combined with atorvastatin on carotid atherosclerotic plaque and myocardial function in elderly patients with coronary artery disease undergoing percutaneous coronary intervention （PCI）. Methods Sixty-six elderly patients with coronary heart disease who underwent PCI in our hospital between January 2014 and February 2016 were divided into the study group and the control group by the random number table method. Both groups were given dual antiplatelet therapy, and the study group was additionally treated with atorvastatin. The status of carotid atherosclerotic plaque [carotid intima-media thickness （IMT）, plaque area （PA）], myocardial function indexes [creatine kinase isoenzyme （CKMB）, cardiac troponin I （cTNI）] before and after treatment, and the incidence of adverse cardiovascular events during treatment were observed. Results After treatment, IMT and PA in two groups significantly decreased, and IMT and PA in study group were significantly lower than those in control group （P〈0.05）; the levels of CKMB and cTNI in control group significantly increased, and the levels of CKMB and cTNI in control group were significantly higher than those in study group （P〈0.05）. The total incidence of adverse cardiovascular events during treatment in study group was significantly lower than that in control group （P〈0.05）. Conclusion Dual antiplatelet therapy combined with atorvastatin can significantly reduce the carotid atherosclerotic plaque and the degree of myocardial damage in elderly patients with coronary heart disease undergoing PCI.
出处
《国际医药卫生导报》
2017年第6期869-872,共4页
International Medicine and Health Guidance News
关键词
冠心病
高龄
经皮冠状动脉介入治疗
阿托伐他汀
双抗血小板
Coronary heart disease
Elderly
Percutaneous coronary intervention
Atorvastatin
Dual antiplatelet therapy
