摘要
目的研究血清学指标多组合检测在慢性乙型肝炎患者中的应用价值，为乙肝的检测提供积极有效地临床依据。方法回顾性分析2013年3月至2015年3月进行血清检测，疑似乙肝患者的血清学指标，共选取患者2700例，对血清学指标的各种组合的乙肝阳性率做出检测，对检测结果进行研究比较。结果对血清学指标的各种组合的乙肝阳性率做出检测，发现不同组合方式乙型肝炎阳性率不同。在HBV—DNA阴性患者中HBsAg阳性率74．0％，阴性率26．0％；HBeAg阳性率13．0％，阴性率87．0％；PreS1Ag阳性率21．1％，阴性率78．9％。在HBV—DNA阳性患者中HBsAg阳性率88．8％，阴性率11．2％；HBeAg阳性率32．1％，阴性率67．9％；PreS1Ag阳性率71．3％，阴性率28．7％；两组数据比较差异有统计学意义（P〈0．05）。阴、阳性患者的五项指标（AST、ALT、GGT、DBIL以及TBIL）均不相同，阴性患者分别为（53．93±31．76）U／L、（61．46±37．88）U／L、（31．59±26．31）U／L、（18．44±8．33）μmol／L、（6．36±3．21）μmol/L、阳性患者分别为（119．44±40．22）U／L、（128．66±51．14）U／L、（71．25±43．78）U／L、（632．62±12．55）μmol／L、（15．37±6．16）μmol／L），两组数据比较差异有统计学意义（P〈0．05）。结论血清学指标多组合检测能够有效的检测乙型肝炎的发生，对疾病的诊断以及及时的治疗有着积极肯定的意义。
Objective To study the application value of multi-combinative detection of serological markers in patients with chronic hepatitis B, and to provide positive and effective clinical basis for the detection of hepatitis B virus. Methods A retrospective study was conducted on the serological test of suspected hepatitis B patients from March 2013 to March 2015. A total of 2 700 patients were selected and the detection rate of hepatitis B virus of various combinations of serological indicators were compared. Results The positive rate of hepatitis B virus was detected by different combinations of serological indexes, and the positive rate of hepatitis B was different in different combinations. In HBV-DNA negative patients, the positive rate of HBsAg was 74.0%, the negative rate was 26.0%; the positive rate of HBeAg was 13.0%, the negative rate was 87.0%; the positive rate of PreS1Ag was 21.1%, the negative rate was 78.9%. In HBV-DNA positive patients, the positive rate of HBsAg was 88.8%, the negative rate was 11.2%; the positive rate of HBeAg was 32.1%, the negative rate was 67.9%; the positive rate of PreS1Ag was 71.3%, the negative rate was 28.7%. There were statistically significant differences between HBV-DNA negative and positive patients （P〈0.05）. There were statistically significant differences in AST, ALT, GGT, DBIL, and TBIL between HBV-DNA negative and positive patients [（53.93±31.76） U/L vs. （119.44±40.22）U/L, （61.46±37.88）U/L vs. （128.66±51.14）U/L, （31.59±26.31）U/L vs. （71.25±43.78）U/L, （18.44±8.33）μmol/L vs. （632.62±12.55）μmol/L, （6.36±3.21）μmol/L vs. （15.37±6.16）μmol/L; P〈0.05]. Conclusion Multi-combinative detection of serological markers can effectively detect the occurrence of hepatitis B, which has a positive and definite significance in the diagnosis of diseases and the timely treatment.
出处
《国际医药卫生导报》
2017年第6期841-843,共3页
International Medicine and Health Guidance News
关键词
血清学指标
慢性乙型肝炎
应用价值
多组合检测
Serological markers
Chronic hepatitis B
Application value
Multi-combinative detection
